Abstract
This study investigated the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and compared patient profiles and outcomes between HPV-positive and HPV-negative groups. This retrospective study included all patients treated for OPSCC in the University Hospitals of Leuven between 2004 and 2012. Paraffin-embedded tumor tissue was available for all patients. Patient characteristics, treatment, and follow-up data were retrieved from medical files. HPV status was determined by immunohistochemical staining for the p16 epitope. Among 94 patients, the prevalence of HPV-positive OPSCC was 22.34%. Compared with HPV-negative tumors, HPV-positive tumors were correlated with less smoking and alcohol consumption, tonsillar sublocalization (P < .05), and younger age. HPV-positive OPSCC was associated with better overall survival (62.2%) compared with HPV-negative OPSCC (42.5%; P = .0588). Among patients with OPSCC, those with HPV exhibited profiles different from those without HPV. HPV-positive OPSCC was associated with better overall survival compared with HPV-negative OPSCC. HPV-positive OPSCC prevalence increased over time.
References
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee R KreimerSilvia Franceschi
Jun 5, 2007·International Journal of Cancer. Journal International Du Cancer·Camille C R Ragin, Emanuela Taioli
Aug 8, 2007·International Journal of Cancer. Journal International Du Cancer·Serge J SmeetsRuud H Brakenhoff
Feb 14, 2008·Journal of the National Cancer Institute·Carole FakhryMaura L Gillison
Mar 13, 2008·Journal of the National Cancer Institute·Maura L GillisonRaphael Viscidi
Feb 4, 2009·Head & Neck·Jay S CooperCorey J Langer
May 11, 2010·The Lancet Oncology·Shanthi MarurArlene A Forastiere
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinGrant A McArthur
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Dec 27, 2011·Annals of Diagnostic Pathology·Jaiyeola Thomas, Thad Primeaux
Jul 13, 2012·Head and Neck Pathology·Jaana Rautava, Stina Syrjänen
Jan 8, 2013·International Journal of Cancer. Journal International Du Cancer·Daniel W VermeerJohn H Lee
Jun 12, 2013·Cancer Research·Randall J KimplePaul M Harari
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Jan 28, 2014·Oral Oncology·Kristen B PytyniaErich M Sturgis
Jan 30, 2014·Cancer Research·Rüveyda DokSandra Nuyts
Feb 13, 2014·British Journal of Cancer·C Grønhøj LarsenC von Buchwald
Mar 13, 2014·International Journal of Radiation Oncology, Biology, Physics·Grace C BlitzerRandall J Kimple
Jun 28, 2014·Cancer Letters·Maria Lina TorneselloFrancesco Caponigro
Aug 6, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liam MastersonPeter K C Goon
Citations
Feb 1, 2018·Head & Neck·Madhava R KanakamedalaSrinivasan Vijayakumar
Apr 3, 2019·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·P MorbiniM Benazzo
Jan 31, 2020·International Journal of Cancer. Journal International Du Cancer·Takuya NakagawaAtsushi Kaneda
May 14, 2020·Cancers·Barbara KoflerWegene Borena
Aug 28, 2020·Cancers·Wegene BorenaBarbara Kofler
Aug 28, 2019·Cancer Medicine·Linnea HaeggblomAnders Näsman
May 1, 2021·Microorganisms·Takuya NakagawaAtsushi Kaneda
Apr 30, 2021·Frontiers in Pharmacology·Steven SimoensEdith Morais