Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study

Brain Research
C GundlahS B Auerbach

Abstract

The aim of the present study was to assess whether there are gender differences in (1) levels of extracellular serotonin (5-HT) in the forebrain, and (2) the effect on 5-HT of a reuptake inhibitor, paroxetine, or a releasing drug, fenfluramine. In vivo microdialysis was used to measure 5-HT in the hypothalamus of male and regularly cycling female rats. Hypothalamic 5-HT was significantly lower in estrous females (0.83 +/- 0.05 pg/sample, n=33) than in male rats (1.04 +/- 0.06 pg, n=38). Levels in diestrous females (0.98 +/- 0.09 pg, n=38) were not significantly different from males. Paroxetine (1 mg/kg) increased hypothalamic 5-HT in males, and diestrous and estrous females to approximately 2 pg/sample. However, the increase in hypothalamic 5-HT produced by a maximally effective dose of paroxetine (10 mg/kg) was significantly greater in male rats and during diestrous than during estrous. d,l-Fenfluramine (10 mg/kg) evoked an increase in extracellular 5-HT to approximately 15 pg/sample in all groups. A higher dose of d,l-fenfluramine (20 mg/kg) produced a significantly greater increase in hypothalamic 5-HT in males than in females during estrous or diestrous. These results are consistent with other evidence that during estrous, ...Continue Reading

References

Aug 1, 1975·Journal of Comparative and Physiological Psychology·B J EverittG Jonsson
Apr 1, 1991·Trends in Pharmacological Sciences·B S McEwen
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·E Martinez-CondeS Diaz
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·P H DesanS F Maier
Aug 11, 1995·Science·M M Weissman, M Olfson
Apr 1, 1997·The American Journal of Psychiatry·M FitzGeraldJ J Mann
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic

❮ Previous
Next ❯

Citations

Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Graham C ParkerDonald V Coscina
Sep 30, 2000·Brain Research. Brain Research Reviews·L Uphouse
Feb 9, 2002·Brain Research. Molecular Brain Research·Naoyuki HironakaHiroaki Niki
Jan 8, 1999·Brain Research. Molecular Brain Research·C GundlahC L Bethea
Oct 16, 2001·Biological Psychology·J A JenkinsF Petty
Oct 31, 2000·Nutrition·M M MeguidF Rossi-Fanelli
Jul 11, 2002·Respiratory Physiology & Neurobiology·M BehanG S Mitchell
Jul 11, 2003·Respiratory Physiology & Neurobiology·Mary BehanGordon S Mitchell
Aug 11, 2004·Clinical Pharmacokinetics·Guillermo GervasiniJulio Benitez
Nov 28, 2013·Pharmacology, Biochemistry, and Behavior·Eelke M S SnoerenRonald S Oosting
Aug 31, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Laura S LubbersVictoria Luine
Mar 13, 2010·Hormones and Behavior·Jutatip GuptarakLynda Uphouse
Mar 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·N R MirzaK B Troelsen
Mar 28, 2009·Journal of Neuroscience Research·Neil DawsonPaul A T Kelly
Jul 15, 2015·ACS Chemical Neuroscience·Hongyan YangAnne M Andrews
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Nov 26, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Neil DawsonPaul A T Kelly
Mar 10, 2010·Brain Research·María Carmen Fernández-GalazLuis M Garcia-Segura
Jul 15, 2006·Psychoneuroendocrinology·Alonso Fernández-GuastiAnnabel Ferreira
Jul 16, 2016·Behavioral Ecology : Official Journal of the International Society for Behavioral Ecology·Shannon Marie GauklerWayne K Potts
Nov 18, 2006·Neuroscience and Biobehavioral Reviews·Kelly Allott, Jennifer Redman
Oct 21, 2004·Brain Research·J GuptarakL Uphouse
May 12, 2005·Behavioral and Cognitive Neuroscience Reviews·Zenab AminC Neill Epperson
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michelle D Jones, Irwin Lucki
Feb 11, 2020·Journal of Neurochemistry·Jason R BorgusB Jill Venton
May 1, 1999·Journal of Neuroendocrinology·G FlüggeE Fuchs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.