Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.

PloS One
Zhi LiZhao-Rong Lun

Abstract

Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a mystery as to why the peritoneal macrophages of rats are naturally resistant to T. gondii infection while those of mice are not. Here, we report that high expression levels and activity of inducible nitric oxide synthase (iNOS) and low levels of arginase-1 (Arg 1) activity in the peritoneal macrophages of rats are responsible for their resistance against T. gondii infection, due to high nitric oxide and low polyamines within these cells. The opposite situation was observed in the peritoneal macrophages of mice. This discovery of the opposing functions of iNOS and Arg 1 in rodent peritoneal macrophages may lead to a better understanding of the resistance mechanisms of mammals, particularly humans and livestock, against T. gondii and other intracellular pathogens.

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Citations

Oct 19, 2013·Parasitology·Cécile GottelandEmmanuelle Gilot-Fromont
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Zhao-Rong LunFrancisco J Ayala
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hong-Mei GuoZhao-Rong Lun
Jan 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Aiping QinAndy Peng Xiang
Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jia ShenZhao-Rong Lun
Jul 26, 2017·Infection and Immunity·William H WitolaXuejin Zhang
Oct 28, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Scott D ZawiejaMariappan Muthuchamy
Feb 3, 2021·ACS Biomaterials Science & Engineering·Qiao LinYuan-Pu Peter Di
Apr 4, 2021·Journal of Clinical Medicine·Afshin DerakhshaniBehzad Baradaran
Sep 1, 2016·Experimental Cell Research·Gyöngyi KudlikFerenc Uher
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Aiping QinAndy Peng Xiang
Nov 16, 2021·Frontiers in Microbiology·Yun-Fu ChenZhao-Rong Lun

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

SPSS

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