PMID: 2108119Feb 1, 1990Paper

Differences in insulin-induced glucose uptake and enzyme activity in running rats

Journal of Applied Physiology
K J RodnickG M Reaven

Abstract

To evaluate the relationship between enhanced insulin action and level of exercise training, in vivo glucose uptake was assessed in the absence of added insulin and during insulin-stimulated conditions for three activity levels of voluntarily trained rats (low 2-5 km/day, medium 6-9 km/day, high 11-16 km/day). After rats rested for 24 h and fasted overnight, glucose uptake was estimated by comparing steady-state serum glucose (SSSG) levels at low insulin (SSSI) concentrations achieved during an insulin suppression test. In the absence of added insulin, SSSI averaged approximately 20 microU/ml and glucose uptake was similar for high runners and younger weight-matched controls. However, with insulin added to sustain SSSI at approximately 35 microU/ml, SSSG was significantly reduced in all runners (P less than 0.02), with the lowest value attained in high runners. Fasting serum triglycerides were also reduced in all runners (P less than 0.05), with the lowest values seen in medium and high runners. The concentration of glycogen in liver and select skeletal muscles at the start of the study was not different between trained and control rats, suggesting that enhanced insulin-stimulated glucose uptake was not the result of lower glyc...Continue Reading

Citations

Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·K Suzuki, K Machida
Sep 2, 1998·The American Journal of Physiology·P E WillisW S Parkhouse
Nov 1, 1990·The American Journal of Physiology·K J RodnickC E Mondon
Dec 12, 2012·European Journal of Nutrition·Carling Yan-Yan ChanKieron Rooney
Nov 11, 1991·The American Journal of Physiology·M Y CortezJ L Ivy
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P DanerydI Karlberg
Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·C E MondonG M Reaven
Nov 10, 2021·The Biochemical Journal·Erik A RichterMark Hargreaves

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