Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention

American Journal of Physiology. Gastrointestinal and Liver Physiology
William L HaslerHenry P Parkman

Abstract

Evidence suggests that distinct mechanisms underlie diabetic and idiopathic gastroparesis. Differences in gastric acid in gastroparesis of different etiologies and varying degrees of gastric stasis are uninvestigated. We tested the hypotheses that 1) gastric pH profiles show differential alteration in diabetic vs. idiopathic gastroparesis and 2) abnormal pH profiles relate to the severity of gastric stasis. Sixty-four healthy control subjects and 44 gastroparesis patients (20 diabetic, 24 idiopathic) swallowed wireless transmitting capsules and then consumed (99m)Tc-sulfur colloid-labeled meals for gastric scintigraphy. Gastric pH from the capsule was recorded every 5 s. Basal pH was higher in diabetic (3.64 +/- 0.41) vs. control subjects (1.90 +/- 0.18) and idiopathic subjects (2.41 +/- 0.42; P < 0.05). Meals evoked initial pH increases that were greater in diabetic (4.98 +/- 0.32) than idiopathic patients (3.89 +/- 0.39; P = 0.03) but not control subjects (4.48 +/- 0.14). pH nadirs prior to gastric capsule evacuation were higher in diabetic patients (1.50 +/- 0.23) than control subjects (0.58 +/- 0.11; P = 0.003). Four-hour gastric retention was similar in diabetic (18.3 +/- 0.5%) and idiopathic (19.4 +/- 0.5%) patients but h...Continue Reading

References

Jan 1, 1991·European Journal of Nuclear Medicine·M HorowitzD J Shearman
Jan 1, 1971·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·K KristenssonP Sourander
Apr 1, 1983·The Journal of Clinical Endocrinology and Metabolism·H SasakiR H Unger
Jun 1, 1994·The Tohoku Journal of Experimental Medicine·T NakamuraF Kasai
Jan 1, 1993·General Pharmacology·A T OzçelikayY Oztürk
May 1, 1997·The American Journal of Physiology·W F LamC B Lamers
Jul 1, 1997·Gastroenterology·E M El-OmarK E McColl
Nov 5, 1997·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S D CarasR W McCallum
Dec 24, 1997·The Journal of Pediatrics·L SigurdssonC Di Lorenzo
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·N T EjskjaerP J Watkins
Jul 27, 2000·European Journal of Gastroenterology & Hepatology·R De GiorgioR Corinaldesi
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·C E M De BlockL F Van Gaal
Nov 13, 2002·The American Journal of Medicine·Karen L JonesMichael Horowitz
Sep 15, 2004·Diabetes Research and Clinical Practice·Fatemeh Nabavizadeh Rafsanjani, Jalal Vahedian
Dec 30, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jameson ForsterRichard W McCallum
Aug 12, 2005·European Journal of Gastroenterology & Hepatology·Sean T MartinGerald C O'Sullivan
May 9, 2006·Gastroenterology·Jan TackVincenzo Stanghellini
Jul 27, 2006·Digestive Diseases and Sciences·Kishore V GaddipatiHenry P Parkman

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Citations

Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Francesco Di Mario, Elisabetta Goni
Oct 26, 2012·Critical Reviews in Clinical Laboratory Sciences·Matthew D Linden, Huyen A Tran
May 20, 2016·Digestive Diseases and Sciences·Radoslav ColeskiWilliam L Hasler
Jun 3, 2014·Expert Review of Gastroenterology & Hepatology·William L Hasler
Mar 10, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N-N SongW-X Xu
Aug 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A-M L WegebergS M Scott
Jul 30, 2011·American Journal of Therapeutics·Khadija H ChaudreyMuhammad Ihsan
Sep 4, 2009·Current Opinion in Gastroenterology·Mitchell L Schubert
Sep 4, 2009·Current Opinion in Gastroenterology·Jan Tack
Apr 25, 2019·Journal of Cellular Physiology·Habibeh Mashayekhi-SardooAmirhossein Sahebkar
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·E BroideM J Rapoport
Jul 20, 2011·Nature Reviews. Gastroenterology & Hepatology·William L Hasler
Nov 2, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I SarosiekR McCallum
Sep 6, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W L HaslerUNKNOWN NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Jun 7, 2012·Clinical Pharmacokinetics·Miroslav DostalekMartina Puzanovova
Feb 29, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Cordula StillhartAnette Müllertz
May 6, 2021·International Journal of Molecular Sciences·Zahra BahadoranAsghar Ghasemi

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