Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.

Neurochemistry International
John L SherwoodZ A Bortolotto

Abstract

Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre LTP involves kainate receptors (KARs). Although it is generally accepted that pre-synaptic KARs play an essential role in frequency facilitation and LTP, their subunit composition remains a matter of significant controversy. We have reported previously that both frequency facilitation and LTP can be blocked by selective antagonism of GluK1 (formerly GluR5/Glu(K5))-containing KARs, but other groups have failed to reproduce this effect. Moreover, data from receptor knockout and mRNA expression studies argue against a major role of GluK1, supporting a more central role for GluK2 (formerly GluR6/Glu(K6)). A potential reason underlying the controversy in the pharmacological experiments may reside in differences in the preparations used. Here we show differences in pharmacological sensitivity of synaptic plasticity at mossy fibre - CA3 synapses depend critically on slice orientation. In transverse slices, LTP of fEPSPs ...Continue Reading

References

Jan 15, 1991·The Journal of Comparative Neurology·N Tamamaki, Y Nojyo
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J C López-GarcíaD Baranes
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A SalinR A Nicoll
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheng YanGeoffrey T Swanson
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frédéric JaskolskiChristophe Mulle
Apr 7, 2004·The European Journal of Neuroscience·Yoshinobu KawamuraHiroyoshi Miyakawa
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jörg Breustedt, Dietmar Schmitz
Jan 5, 2005·Trends in Pharmacological Sciences·Frédéric JaskolskiChristophe Mulle
Nov 2, 2005·Nature Reviews. Neuroscience·Roger A Nicoll, Dietmar Schmitz
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arnaud RuizChristophe Mulle
Feb 20, 2007·Journal of Neuroscience Methods·William W Anderson, Graham L Collingridge
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paulo S PinheiroChristophe Mulle
Jul 29, 2008·Neuropharmacology·Graham L CollingridgeMichael Spedding
Sep 2, 2008·Neuropharmacology·David PerraisChristophe Mulle
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo ScottDmitri A Rusakov
Dec 27, 2008·Neuron·Hyung-Bae Kwon, Pablo E Castillo

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Citations

Mar 16, 2017·Scientific Reports·Javier Castro-HernándezDavid I Finkelstein
Feb 27, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Talvinder S SihraAntonio Rodríguez-Moreno
Dec 24, 2019·Neuroscience·Sergio Valbuena, Juan Lerma

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