Differences in Liver Graft Survival by Recipient Sex

Transplantation Direct
Alexia I De SimoneBethany J Foster

Abstract

We aimed to characterize patterns of differences in liver graft failure rates by recipient sex, accounting for the modifying effects of donor sex and recipient age. We evaluated 144 212 first deceased donor liver transplant recipients [1988-2019; Scientific Registry of Transplant Recipients (SRTR)]. We used multivariable time-varying Cox models, considering a recipient sex by donor sex by recipient age (0-12, 13-24, 25-44, ≥45 y) interaction. Among recipients of male donors, females <45 y had higher graft failure rates than males of the same age, but none of these differences were statistically significant [0-12 y: adjusted hazard ratio (aHR) 1.17 (0.98, 1.40); 13-24 y: aHR 1.18 (0.96, 1.46); 25-44 y: aHR 1.11 (0.96, 1.28)]; there was no material or statistically significant difference between female and male recipients ≥45 y [aHR 1.01 (0.97, 1.06)]. When the donor was female, recipients <45 y showed no statistically significant differences in graft outcomes by recipient sex [0-12 y: aHR 0.91 (0.74, 1.11); 13-24 y: aHR 0.98 (0.77, 1.25); 25-44 y: aHR 0.86 (0.73, 1.01)], whereas female recipients ≥45 y had significantly lower graft failure rates [aHR 0.85 (0.81, 0.89)] than males of the same age. Among recipients of female donor...Continue Reading

References

Jul 25, 1991·The New England Journal of Medicine·B Healy
Nov 1, 1990·Digestive Diseases and Sciences·P PillayT E Starzl
Apr 15, 1996·Transplantation·H R Doyle, I R Marino
Dec 27, 1996·Transplantation·B K BrooksG B Klintmalm
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DevlinR Williams
Oct 6, 2000·Journal of the National Cancer Institute·K Arnold
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vinod K RustgiChristine Tolleris
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Martin ZeierEberhard Ritz
Jan 22, 2003·JAMA : the Journal of the American Medical Association·Vivian W Pinn
Jan 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Martínez-LlordellaA Sánchez-Fueyo
Feb 25, 2009·Seminars in Liver Disease·Stuart J Knechtle, Jean Kwun
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C LaiN A Terrault
Apr 5, 2011·Allergy, Asthma & Immunology Research·Inseon S Choi
May 10, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michelle M KittlesonJon A Kobashigawa
Nov 30, 2011·Transplantation·Bethany J FosterJames A Hanley
Dec 14, 2011·Autoimmunity Reviews·Sabine Oertelt-Prigione
Aug 22, 2012·Gender Medicine·Jane C TanManisha Desai
Dec 18, 2013·Clinical Transplantation·Christina A SpiveyDean Billheimer
Feb 25, 2015·Cellular Immunology·Abhishek TrigunaiteTrine N Jørgensen
Feb 28, 2015·Aging Cell·Carmen Giefing-KröllBeatrix Grubeck-Loebenstein
Jun 10, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca Saverio BelliUNKNOWN Liver Match Investigators
Jul 5, 2015·Current Allergy and Asthma Reports·Joe G Zein, Serpil C Erzurum
Jul 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B J FosterJ Conway
Nov 21, 2015·Transplantation·Bethany J FosterVicky Lee Ng
Jan 12, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Sapir-PichhadzeS J Kim
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jianle WangMontserrat C Anguera
May 14, 2016·Patient Preference and Adherence·Marie A Chisholm-BurnsErin K Kaplan
Jan 1, 2015·International Journal of Statistics in Medical Research·Yang Liu, Anindya De
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Nov 30, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Yefei Zhang
Apr 4, 2017·Clinics in Liver Disease·Renumathy Dhanasekaran
Jun 9, 2017·Journal of the American Society of Nephrology : JASN·Fanny LepeytreBethany J Foster
Oct 22, 2017·Human Immunology·Josh Levitsky, Sandy Feng
Mar 6, 2018·Current HIV/AIDS Reports·Eileen P Scully
Mar 27, 2018·Trends in Immunology·Ashley LauStefan G Tullius
Jul 10, 2018·Nature Reviews. Neurology·Maria Teresa FerrettiUNKNOWN Women’s Brain Project and the Alzheimer Precision Medicine Initiative
Jul 25, 2019·World Journal of Gastroenterology : WJG·Nitin AbrolTimucin Taner

❮ Previous
Next ❯

Software Mentioned

Statistical Analysis
plus
LIVER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Fanny LepeytreBethany J Foster
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Courtenay M HolscherDorry L Segev
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S John SwansonKevin C Abbott
Clinical Journal of the American Society of Nephrology : CJASN
Kyle J Van ArendonkDorry L Segev
© 2021 Meta ULC. All rights reserved