PMID: 6165838Jun 1, 1981Paper

Differences in mechanisms of transformation by independent feline sarcoma virus isolates

Journal of Virology
F H ReynoldsJ R Stephenson

Abstract

The Gardner and Snyder-Theilen isolates of feline sarcoma virus (FeSV) have previously been shown to encode high-molecular-weight polyproteins with a transforming function and an associated tyrosine-specific protein kinase activity. Cells transformed by these viruses exhibited morphological alterations, elevated levels of phosphotyrosine, and a reduced capacity for binding epidermal growth factor. In addition, polyproteins encoded by both of these FeSV isolates bound to, and phosphorylated tyrosine acceptor sites within, a 150,000-molecular-weight cellular substrate (P150). McDonough FeSV-transformed cells resembled Gardner and Snyder-Theilen FeSV transformants with respect to morphological changes and a reduced capacity for epidermal growth factor binding. in contrast to the other two FeSV isolates, however, McDonough FeSV encoded as its major translational product a high-molecular-weight polyprotein with probable transforming function but without protein kinase activity detectable under similar assay conditions. Moreover, total cellular levels of phosphotyrosine remained unaltered in McDonough FeSV-transformed cells, and the major McDonough FeSV polyprotein translational product lacked binding affinity for P150. These finding...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J R StephensonM Essex
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M S Collett, R L Erikson
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C J SherrM Essex
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·O N WitteD Baltimore
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F H ReynoldsJ R Stephenson
Jun 1, 1979·Journal of Virology·A E FrankelS A Aaronson
May 30, 1970·Nature·M B GardnerC G Rickard
Mar 15, 1969·Nature·S P Snyder, G H Theilen
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T Hunter, B M Sefton
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M BarbacidS G Devare
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M ShibuyaJ R Stephenson

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Citations

Jan 1, 1983·Journal of Cellular Biochemistry·F VeroneseJ R Stephenson
Jan 1, 1992·Cancer Investigation·L J RezankaJ C Neil
Feb 1, 1987·Journal of Cellular Biochemistry·C W RettenmierC J Sherr
Jan 1, 1988·Molecular and Cellular Biology·D K MorrisonT M Roberts
Nov 1, 1988·Molecular and Cellular Biology·S MajumderP Besmer
Nov 15, 1988·Biochimica Et Biophysica Acta·C J Sherr
Oct 1, 1984·Molecular and Cellular Biology·M F RousselC J Sherr
Sep 1, 1984·Journal of Virology·S J AndersonC J Sherr
Apr 15, 1983·Virology·N HeisterkampJ R Stephenson

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