Differences in mechano-transducer channel kinetics underlie tonotopic distribution of fast adaptation in auditory hair cells

Journal of Neurophysiology
A J Ricci

Abstract

The first step in audition is a deflection of the sensory hair bundle that opens mechanically gated channels, depolarizing the sensory hair cells. Two mechanism of adaptation of mechano-electric transducer (MET) channels have been identified in turtle auditory hair cells. The rate of fast adaptation varies tonotopically and is postulated to underlie a mechanical tuning mechanism in turtle auditory hair cells. Fast adaptation is driven by a calcium-dependent feedback process associated with MET channels. The purpose of this paper is to test the hypothesis that fast adaptation contributes to MET channel kinetics and that variations in channel kinetics underlie the tonotopic distribution of fast adaptation. To test for kinetic differences, the open channel blocker dihydrostreptomycin (DHS) was used. DHS blocked MET currents from low-frequency cells (IC(50) = 14 +/- 2 microM) more effectively than high-frequency cells (IC(50) = 75 +/- 5 microM), suggesting differences in MET channel properties. DHS block showed similar calcium sensitivities at both papilla locations. No difference in calcium permeation or block of the transducer channels was observed, indicating that the DHS effect was not due to differences in the channel pore. Sl...Continue Reading

References

Nov 14, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Colquhoun, A G Hawkes
Mar 1, 1991·The Journal of Physiology·A C CrawfordR Fettiplace
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A AssadD P Corey
Sep 1, 1988·The Journal of Physiology·F Jørgensen, H Ohmori
Dec 1, 1989·The Journal of Physiology·A C CrawfordR Fettiplace
Jan 1, 1989·The Japanese Journal of Physiology·H Ohmori
Oct 22, 1988·The Journal of Comparative Neurology·M G Sneary
Jul 1, 1985·The Journal of Physiology·A C Crawford, R Fettiplace
Jan 1, 1993·British Journal of Pharmacology·J W LaneO P Hamill
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Jaramillo, A J Hudspeth
Jan 1, 1995·The Journal of General Physiology·J J ArtR Fettiplace
Jan 1, 1994·Neuron·A J Hudspeth, P G Gillespie
Aug 1, 1997·Current Opinion in Neurobiology·A Hudspeth
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·E A LumpkinA J Hudspeth
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y ChoeA J Hudspeth
Jul 22, 1999·Annals of the New York Academy of Sciences·E M JonesR Fettiplace
Nov 24, 1999·Journal of Neurophysiology·Y C WuR Fettiplace
Apr 15, 2000·The Journal of Physiology·A J RicciR Fettiplace
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·P MartinA J Hudspeth
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J HudspethP Martin
Feb 22, 2001·Trends in Neurosciences·R FettiplaceC M Hackney

❮ Previous
Next ❯

Citations

May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Volker BormuthPascal Martin
Jun 15, 2006·The Journal of Membrane Biology·A J RicciS M Van Netten
May 29, 2009·Pflügers Archiv : European journal of physiology·Robert Fettiplace
Sep 1, 2011·Journal of the Association for Research in Otolaryngology : JARO·Ruben S StepanyanGregory I Frolenkov
Nov 29, 2011·International Journal of Otolaryngology·M E HuthA G Cheng
Nov 29, 2011·Pharmacology & Therapeutics·E L AndradeJ B Calixto
Jul 5, 2006·The European Journal of Neuroscience·Toshihiko KanekoAnthony W Gummer
Jun 8, 2004·The Journal of Physiology·H E FarrisA J Ricci
Dec 20, 2016·The Journal of Clinical Investigation·Dale W HaileyDavid W Raible
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Maryline BeurgRobert Fettiplace
Jul 23, 2005·The Journal of Physiology·J R Waguespack, A J Ricci
Feb 13, 2016·Physiological Reports·Laura F Corns, Walter Marcotti
Jul 6, 2014·Physiological Reviews·Robert Fettiplace, Kyunghee X Kim
May 16, 2017·Frontiers in Cellular Neuroscience·Paromita MajumderJonathan E Gale
Nov 3, 2017·Frontiers in Cellular Neuroscience·Mary E O'SullivanAlan G Cheng
Mar 27, 2018·International Journal of Toxicology·David V GauvinRachel Tapp
May 20, 2016·PloS One·Xudong WuDavid P Corey
Sep 11, 2003·Current Opinion in Neurobiology·Robert Fettiplace, Anthony J Ricci
Aug 3, 2021·Neural Plasticity·Peng WuHe Li
Aug 20, 2021·The Journal of General Physiology·Maryline BeurgRobert Fettiplace

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.