Differences in molecular mechanisms of K+ clearance in the auditory sensory epithelium of birds and mammals

The Journal of Experimental Biology
Viviane WilmsHans Gerd Nothwang

Abstract

Mechanoelectrical transduction in the vertebrate inner ear is a highly conserved mechanism that is dependent on K+ influx into hair cells. Here, we investigated the molecular underpinnings of subsequent K+ recycling in the chicken basilar papilla and compared them with those in the mammalian auditory sensory epithelium. As in mammals, the avian auditory hair cell uses KCNQ4, KCNMA1 and KCNMB1 in its K+ efflux system. Expression of KCNQ1 and KCNE1 suggests an additional efflux apparatus in avian hair cells. Marked differences were observed for K+ clearance. In mammals, KCC3, KCC4, Kir4.1 and CLC-K are present in supporting cells. Of these, only CLC-K is expressed in avian supporting cells. Instead, they possess NKCC1 to move K+ across the membrane. This expression pattern suggests an avian clearance mechanism reminiscent of the well-established K+ uptake apparatus present in inner ear secretory cells. Altogether, tetrapod hair cells show similar mechanisms and supporting cells show distinct molecular underpinnings of K+ recycling.

References

Jun 1, 1990·Biophysical Journal·M Zidanic, W E Brownell
Jan 1, 1989·The Journal of Physiology·B M JohnstoneE Syková
Jan 1, 1987·Hearing Research·K P SteelG R Bock
Oct 1, 1970·The Annals of Otology, Rhinology, and Laryngology·E IshiyamaE W Keels
Oct 1, 1996·Hearing Research·S ErichsenM Hultcrantz
Nov 3, 1998·Cell and Tissue Research·J LautermannE Winterhager
Apr 7, 2000·Brain Research. Brain Research Reviews·T KikuchiJ C Adams
Jul 5, 2002·Audiology & Neuro-otology·Philine Wangemann
Jun 1, 1962·Journal of Cellular and Comparative Physiology·R S SCHMIDT, C FERNANDEZ
Aug 1, 1963·Comparative Biochemistry and Physiology·C G JOHNSTONEB M JOHNSTONE
Sep 1, 1963·Comparative Biochemistry and Physiology·R S SCHMIDT
Feb 10, 2006·Hearing Research·Chunyan QuBradley A Schulte
Sep 23, 2006·Physiology·Hiroshi Hibino, Yoshihisa Kurachi
Aug 3, 2007·American Journal of Physiology. Cell Physiology·Florian LangPhiline Wangemann
Sep 11, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Pavel Mistrik, Jonathan Ashmore
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Kenneth B Gagnon, Eric Delpire
Apr 18, 2013·PloS One·Rachel Clemens GrishamTeresa Nicolson
Jul 31, 2013·The Journal of Biological Chemistry·Heike EhmannHans Gerd Nothwang
Nov 26, 2013·Molecular Biology and Evolution·Anna-Maria HartmannOlaf R P Bininda-Emonds
Aug 6, 2014·Journal of the Association for Research in Otolaryngology : JARO·Olga SchuthSonja J Pyott
Nov 21, 2016·Brain, Behavior and Evolution·Benjamin PawlikHans Gerd Nothwang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.