Differences in mouse models of diabetes mellitus in studies of male reproduction

International Journal of Andrology
Jason O'NeillCon Mallidis

Abstract

Diabetes Mellitus (DM) has been found to have subtle yet profound effects on the metabolic status of the testis, the expression of numerous spermatogenic genes and is associated with increased numbers of sperm with nuclear DNA damage. The precise mechanism causing these detrimental effects remains unknown. The presence of increased levels of the most prominent member (carboxymethyllysine - CML) of the advanced glycation end product adducts and their receptor (RAGE) in the reproductive tract of DM men has provided a new avenue for research. As there are suspicions that the antibiotic (streptozotocin - STZ) employed to induce DM is also capable of causing oxidative stress and DNA damage, we compared CML and RAGE levels in the reproductive tract and sperm nDNA status of STZ mice with the levels in the Ins(2Akita) mouse to determine which more closely mimics the situation described in the human diabetic. CML was observed in the testes, epididymes and sperm of all animals. Sperm from DM mice showed particularly strong CML immunolocalization in the acrosomal cap, the equatorial region and whenever present, cytoplasmic droplets. Although increased, the level of CML on the sperm of the STZ and Ins(2Akita) DM mice did not reach statisti...Continue Reading

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Citations

Oct 17, 2012·Journal of Assisted Reproduction and Genetics·Rohini BosePratap Kumar
May 3, 2011·Human Reproduction·C MallidisS Schlatt
May 23, 2014·European Journal of Pharmacology·Narayana KilarkajeMaie M Al-Bader
Sep 17, 2011·Andrologia·S La VigneraA E Calogero
May 16, 2014·Reproductive Sciences·Narayana Kilarkaje, Maie M Al-Bader
Nov 15, 2017·Human Reproduction Update·Constanze C MareschThomas Linn
Sep 12, 2019·Scientific Reports·Constanze C MareschThomas Linn
Oct 18, 2019·Frontiers in Endocrinology·Anastasia DimakopoulouWaljit S Dhillo
Feb 13, 2020·Reproductive Toxicology·Temidayo S Omolaoye, Stefan S du Plessis
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Athira JohnsonZwe-Ling Kong

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