Differences in mRNA expression of adipocyte-derived factors in response to fasting, refeeding and leptin

Biochimica Et Biophysica Acta
Fabrice Bertile, Thierry Raclot

Abstract

The present study examines whether and to what extent the profiles of adipose-derived factors are altered in epididymal and subcutaneous adipose tissues of long-term fasted/refed and of fasted rats treated by recombinant leptin. Fasting was characterized by three successive metabolic phases. Minor differences in the time-course and magnitude of response were detected between the two adipose sites. Leptin, adiponectin, resistin, adiponutrin, and insulin-like growth factor-1 (IGF-1) gene expressions differentially decreased according to the fasting duration. mRNA levels reached a minimum in late fasting for these secreted factors, being decreased by 60-90% for adiponectin, resistin, and IGF-1, 95-98% for leptin and by 100% for adiponutrin. Refeeding partially or totally restored their mRNA expression in epididymal adipose. Expression levels of apolipoprotein E (ApoE), angiotensinogen (AGT), adipsin and macrophage migration inhibitory factor (MIF) were either unchanged or slightly affected. In leptin-treated rats, leptin mRNA concentrations were significantly decreased in phase 2 of fasting (by 85%) from levels in control phosphate-buffered saline (PBS)-treated rats in both tissues. Leptin treatment also decreased resistin mRNA le...Continue Reading

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Citations

Jan 13, 2006·Pflügers Archiv : European journal of physiology·P OliverA Palou
May 11, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P OliverA Palou
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Jul 14, 2010·The Journal of Nutritional Biochemistry·Fabrice Bertile, Thierry Raclot
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