Differences in Multi-Modal Ultrasound Imaging between Triple Negative and Non-Triple Negative Breast Cancer

Ultrasound in Medicine & Biology
Ziyao LiTong Wu

Abstract

The objective of this study was to identify multi-modal ultrasound imaging parameters that could potentially help to differentiate between triple negative breast cancer (TNBC) and non-TNBC. Conventional ultrasonography, ultrasound strain elastography and 3-D ultrasound (3-D-US) findings from 50 TNBC and 179 non-TNBC patients were retrospectively reviewed. Immunohistochemical examination was used as the reference gold standard for cancer subtyping. Different ultrasound modalities were initially analyzed to define TNBC-related features. Subsequently, logistic regression analysis was applied to TNBC-related features to establish models for predicting TNBC. TNBCs often presented as micro-lobulated, markedly hypo-echoic masses with an abrupt interface (p = 0.015, 0.0015 and 0.004, compared with non-TNBCs, respectively) on conventional ultrasound, and showed a diminished retraction pattern phenomenon in the coronal plane (p = 0.035) on 3-D-US. Our findings suggest that B-mode ultrasound and 3-D-US in multi-modality ultrasonography could be a useful non-invasive technique for differentiating TNBCs from non-TNBCs.

References

Jan 1, 1990·Ultrasound in Medicine & Biology·D D AdlerD Quinn-Reid
Sep 24, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D RottenL Zerat
Nov 7, 1999·Radiology·H M ZonderlandA E van Voorthuisen
Jan 15, 2004·IEEE Transactions on Medical Imaging·Sheng-Fang HuangWoo Kyung Moon
Feb 18, 2006·Radiology·Ako ItohTakeshi Matsumura
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Socorro María Rodríguez-PinillaJosé Palacios
Oct 24, 2006·AJR. American Journal of Roentgenology·Andrew J EvansEleanor Cornford
Jul 26, 2007·BMC Cancer·Marc TischkowitzWilliam D Foulkes
May 3, 2008·The Breast : Official Journal of the European Society of Mastology·Hakan MersinKaptan Gülben
Aug 13, 2008·Expert Opinion on Therapeutic Targets·Kai-Keen ShiuJorge S Reis-Filho
Nov 15, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Eriko TohnoHiroshi Watanabe
Oct 26, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yasuyuki Kojima, Hiroko Tsunoda
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sunil BadveJorge S Reis-Filho
Dec 1, 2010·Academic Radiology·Ji Hye LeeByung Joo Song
Dec 8, 2010·Seminars in Roentgenology·Gary J WhitmanAna Maria Gonzalez-Angulo
Aug 19, 2011·Journal of breast cancer·Yoon Jung ChoiChan Heun Park
May 4, 2012·Journal of Pharmacy Practice·Carrie L Griffiths, Jacqueline L Olin
Jan 25, 2013·AJR. American Journal of Roentgenology·Abid IrshadAmy Campbell
Jun 19, 2013·Seminars in Ultrasound, CT, and MR·Rosalind P CandelariaGary J Whitman
Aug 2, 2015·European Radiology·Martina Džoić DominkovićBoris Brkljačić

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Citations

Oct 25, 2016·Cancer Medicine·Jun-Long SongSheng-Rong Sun
Feb 28, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Gamze DurhanSema Hücümenoğlu
Nov 10, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Qiang GuoJiawei Tian
Nov 18, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jieun KohEun-Kyung Kim
Nov 19, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Kai ZhuJuan Li
Apr 28, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lu TianJinhua Cai
Aug 12, 2020·Asia-Pacific Journal of Clinical Oncology·Hao CuiJiawei Tian

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