Differences in patient age distribution between influenza A subtypes.

PloS One
Hossein KhiabanianRaul Rabadan

Abstract

Since the spring of 1977, two subtypes of influenza A virus (H3N2 and H1N1) have been seasonally infecting the human population. In this work we study the distribution of patient ages within the populations that exhibit the symptomatic disease caused by each of the different subtypes of seasonal influenza viruses. When the publicly available extensive information is pooled across multiple geographical locations and seasons, striking differences emerge between these subtypes. We report that the symptomatic flu due to H1N1 is distributed mainly in a younger population relative to H3N2. (The median age of the H3N2 patients is 23 years while H1N1 patients are 9 years old.) These distinct characteristic spectra of age groups, possibly carried over from previous pandemics, are consistent with previous reports from various regional population studies and also findings on the evolutionary dynamics of each subtype. Moreover, they are relevant to age-related risk assessments, modeling of epidemiological networks for specific age groups, and age-specific vaccine design. Recently, a novel H1N1 virus has spread around the world. Preliminary reports suggest that this new strain causes symptomatic disease in the younger population in a simila...Continue Reading

References

Jun 1, 1985·American Journal of Epidemiology·A S MontoI M Longini
Mar 15, 1995·American Journal of Epidemiology·A S MontoA Talsma
Jul 4, 1998·The Journal of Infectious Diseases·L SimonsenK Fukuda
Mar 5, 2002·Bulletin of the History of Medicine·Niall P A S Johnson, Juergen Mueller
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Feb 24, 2006·Emerging Infectious Diseases·Edwin D Kilbourne
Oct 19, 2007·Journal of Virology·Yiming BaoDavid Lipman
Apr 18, 2008·Nature·Andrew RambautEdward C Holmes
May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
Mar 2, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kiyomitsu MiyachiRaleigh W Hankins

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Citations

Feb 23, 2010·PloS One·Antoine NougairèdeXavier de Lamballerie
Jul 13, 2011·PloS One·Drosos E KarageorgopoulosMatthew E Falagas
May 30, 2013·PloS One·Antonella Liccardo, Annalisa Fierro
Nov 6, 2013·American Journal of Epidemiology·Talia M QuandelacyEdward Goldstein
Feb 22, 2011·The European Physical Journal. E, Soft Matter·A Fierro, A Liccardo
Apr 15, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G NoelP Minodier
Aug 11, 2015·Influenza and Other Respiratory Viruses·Saverio CainiUNKNOWN Global Influenza B Study
Aug 9, 2011·Vaccine·Guus F RimmelzwaanAlbert D M E Osterhaus
Mar 5, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A AntónT Pumarola
Mar 8, 2018·PLoS Computational Biology·Elizabeth C LeeShweta Bansal
Nov 15, 2018·Influenza and Other Respiratory Viruses·Cécile SoutyThierry Blanchon
Jun 4, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Lidia Redondo-Bravo The Spanish Influenza Sentinel Surveillance System
Feb 4, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A NougairedeX de Lamballerie

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Methods Mentioned

BETA
Genome Sequencing

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