PMID: 6806190May 1, 1982

Differences in phagocytosis and killing by alveolar macrophages from humans, rabbits, rats, and hamsters

Infection and Immunity
B Y NguyenJ R Hoidal

Abstract

Phagocytosis and killing by alveolar macrophages from humans, rabbits, rats, and hamsters, were compared in vitro. In the absence of serum opsonins, human alveolar macrophages could phagocytize Staphylococcus aureus Cowan I (protein A positive), but not S. aureus EMS (protein A negative) or Pseudomonas aeruginosa MN. In contrast, rabbit, rat, and hamster alveolar macrophages did not phagocytize S. aureus Cowan I or other nonopsonized bacteria. Human alveolar macrophages, but not other species, stained positively with fluorescein isothiocyanate-conjugated protein A. When opsonized bacterial were studied, phagocytosis by human, rabbit, and hamster alveolar macrophages was found to be mediated by both Fc and C3 receptors. However, only Fc receptor-mediated phagocytosis of bacteria was demonstrated for rat alveolar macrophages. Differences were also found in the kinetics of bacterial killing by alveolar macrophages from different species. Human and rabbit alveolar macrophages rapidly killed opsonized S. aureus Cowan I. However, bacterial killing by hamster alveolar macrophages proceeded at a slower rate, and rat alveolar macrophages completely failed to kill S. aureus. These significant differences in the function of alveolar macro...Continue Reading

Citations

Jan 1, 1989·Critical Reviews in Toxicology·D B Warheit
Jul 19, 2013·Seminars in Immunopathology·Evelyn GuiradoGilla Kaplan
Jan 1, 1990·American Journal of Respiratory Cell and Molecular Biology·F van IwaardenL M van Golde
Nov 1, 1989·American Journal of Respiratory Cell and Molecular Biology·P H NibberingR van Furth
Mar 20, 2001·Infection and Immunity·P MancusoM Peters-Golden
Dec 6, 2000·American Journal of Respiratory Cell and Molecular Biology·P Mancuso, M Peters-Golden
Mar 19, 2005·Pediatric Research·Sylvia CraigFred Markham
Aug 14, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Huy A NguyenLarry S Schlesinger
Jan 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R J HelmkeJ A Mangos
May 25, 2004·Infection and Immunity·Jianmin ZhangHenry Koziel
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld

Related Concepts

Complement C3 precursor
Cricetus
Macrophage
Mesocricetus
Phagocytosis
Pseudomonas aeruginosa
Pulmonary Alveolar Structure
August Rats
Complement Receptor Type 1
Fc Receptor

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