Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni )

Journal of Circadian Rhythms
Manuel Miranda-AnayaMauricio Díaz-Muñoz

Abstract

Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse Neotomodon alstoni is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. We report differences in the free running circadian locomotor activity rhythm and in the effects of light pulses between lean and obese mice. Also, the photo-induced expression of the c-Fos protein and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN) were examined at circadian time (CT) 14 and 22. We show that obese mice have a larger dispersion of the period of circadian locomotor rhythm in constant darkness. Photic induced phase shifts are nearly 50% shorter at CT 14, and 50% larger at CT 22 than in lean mice. The photoinduction of VIP in the SCN at CT 22 was larger in obese mice, which may be related to the differences observed in photic phase shifting. Our work indicates that the obesity in Neotomodon has effects on the neural mechanisms that regulate the circadian system.

References

Jan 1, 1997·Annual Review of Medicine·R Y Moore
Nov 24, 1998·Metabolism: Clinical and Experimental·B L BlackR S Surwit
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R E Mistlberger, M M Holmes
Feb 24, 2001·The European Journal of Neuroscience·H E ReedH D Piggins
Dec 31, 2002·Neuroscience Letters·Rebecca A Prosser, Harriet E Bergeron
Apr 17, 2003·The Journal of Endocrinology·H D Piggins, D J Cutler
Jun 28, 2003·Journal of Biological Rhythms·Johanna H Meijer, William J Schwartz
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·J ASCHOFF
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·C S PITTENDRIGH
Sep 27, 2003·Biochemical and Biophysical Research Communications·Chihiro KawaguchiKatsuya Nagai
Mar 25, 2004·Journal of Biological Rhythms·Dominique SageDenis Becquet
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Feb 16, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M S Bray, M E Young
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paola C YannielliDiego A Golombek
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Dec 25, 2007·Annual Review of Psychology·Hans-Rudolf Berthoud, Christopher Morrison
May 20, 2008·Journal of Biological Rhythms·A T L Hughes, H D Piggins
Sep 9, 2008·Cell·Carla B GreenJoseph Bass
Oct 22, 2008·The Journal of Physiology·Jorge MendozaEtienne Challet
Jun 9, 2009·Journal of Neuroendocrinology·A N InyushkinR E J Dyball
Oct 27, 2009·Endocrine Reviews·Oren Froy
Nov 11, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M-C HsiehK-R Shieh
Jan 12, 2010·Physiology & Behavior·Maria Assumpció Sans-FuentesTrinitat Cambras
Feb 26, 2010·The European Journal of Neuroscience·Joanna M DragichChristopher S Colwell
Mar 10, 2010·Disease Models & Mechanisms·Arion J KennedyAlyssa H Hasty
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Sep 30, 2010·Journal of Neuroendocrinology·J MendozaC Grundschober
Nov 30, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Deanna Marie ArbleFred W Turek
Dec 4, 2010·Science·Joseph Bass, Joseph S Takahashi
Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R A Hut, D G M Beersma
Oct 18, 2011·Physiology & Behavior·Vania Carmona-AlcocerManuel Miranda-Anaya
Mar 30, 2013·Current Opinion in Neurobiology·Michael MenakerMichael T Sellix
Apr 3, 2013·Journal of Physiology, Paris·Diego A GolombekJuan J Chiesa
Mar 29, 2014·Endocrine Reviews·Laura K Fonken, Randy J Nelson
Jun 4, 2014·International Review of Psychiatry·Kelly Glazer Baron, Kathryn J Reid
Jul 7, 2015·Biochimie·Edith GrosbelletEtienne Challet

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Citations

Jun 16, 2017·Chronobiology International·Moisés Pérez-MendozaManuel Miranda-Anaya
Jan 26, 2018·Chronobiology International·Moisés Pérez-MendozaManuel Miranda-Anaya

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