Differences in projection patterns between large and small corticothalamic terminals

The Journal of Comparative Neurology
S C Van Horn, S M Sherman

Abstract

We injected tracer into wide regions of visual cortex in the cat to produce retrograde and orthograde labeling in the thalamus, chiefly in the lateral geniculate nucleus and lateral posterior-pulvinar complex (LP-Pulvinar). We used the electron microscope to measure the sizes of orthogradely labeled terminals in thalamus and used these measurements to help determine whether the terminals were "RL" (large, presumed excitatory) or "RS" (small, presumed excitatory). We also distinguished reciprocal regions, which were zones of corticothalamic feedback defined by the presence of many retrogradely labeled cell bodies and orthogradely labeled terminals, from nonreciprocal regions, which were zones of feedforward corticothalamic projections defined by the presence of orthogradely labeled terminals alone. The lateral geniculate nucleus, a reciprocal region, had retrogradely labeled cell bodies as well as labeled RS terminals. Likewise, reciprocal regions in LP-Pulvinar were dominated by labeled RS terminals. In contrast, nonreciprocal regions were dominated by labeled RL terminals. Based on other evidence of corticothalamic projections that RL and RS terminals derive, respectively, from layer 5 and layer 6, we suggest the same relation...Continue Reading

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Citations

Dec 8, 2009·Nature Neuroscience·Brian B TheyelS Murray Sherman
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Angela N ViaeneS Murray Sherman
Nov 5, 2010·Journal of Neurophysiology·Angela N ViaeneS Murray Sherman
Mar 8, 2013·PloS One·Rajiv WijesingheAaron J Camp
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca A Berman, Robert H Wurtz
Jan 15, 2014·Autonomic Neuroscience : Basic & Clinical·Ruei-Jen ChiouChen-Tung Yen
Jan 30, 2013·The Journal of Physiology·Iraklis Petrof, S Murray Sherman
Aug 21, 2007·Current Opinion in Neurobiology·S Murray Sherman
Mar 18, 2009·The European Journal of Neuroscience·Robert F HessKathy T Mullen
Nov 23, 2012·The Journal of Comparative Neurology·W Alex FoxworthyM Alex Meredith
Aug 21, 2010·The Journal of Physiology·Farran Briggs, W Martin Usrey
May 5, 2009·Hearing Research·C CappeP Barone
Aug 26, 2014·Frontiers in Integrative Neuroscience·Olivier Joly, Edit Frankó
Apr 27, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Holly D H BrownAntony B Morland
May 14, 2004·Journal of Neurophysiology·Iva Reichova, S Murray Sherman
Jan 9, 2008·The Journal of Comparative Neurology·Daniel A Llano, S Murray Sherman
Jun 17, 2011·Journal of Neurophysiology·S Murray Sherman, R W Guillery
Jul 1, 2020·The Journal of Physiology·Josephine AnsorgePatrik Krieger
Jan 30, 2015·Journal of Neurophysiology·Iraklis PetrofS Murray Sherman
Oct 12, 2017·Frontiers in Neuroanatomy·Audrey Mercer, Alex M Thomson
Nov 24, 2020·The Journal of Comparative Neurology·Bruno Oliveira Ferreira de SouzaDenis Boire
Jul 24, 2021·Cerebral Cortex Communications·Reza Abbas FarishtaChristian Casanova

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