Differences in proliferative rate and collagen lattice contraction between endotenon and synovial fibroblasts

The Journal of Hand Surgery
U KhanD A McGrouther

Abstract

Injured and surgically repaired tendons heal with the formation of scar tissue. Scar tissue represents 1 of the most unpredictable factors contributing to postoperative morbidity. The main cell involved in scar formation is the fibroblast. The relative activity of fibroblasts from the fibro-osseous sheath (the tissue surrounding the tendon in zone II) and the endotenon (the core of the tendon) with respect to proliferation and the ability to contract a collagen lattice were compared in vitro. The fibroblasts derived from the fibro-osseous sheath were more active in both these respects. In addition, the amount of matrix metalloproteinase activity was found to be greater for the fibro-osseous sheath fibroblasts, implying a greater capacity to degrade and disorganize connective tissue and thus migrate. These results imply that the fibro-osseous fibroblasts represent a more active population of cells compared with endotenon fibroblasts, and perhaps should be specifically targeted in future modes of therapy.

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Citations

May 11, 2005·Hand Clinics·Jeffrey LuoT C He
Mar 27, 2004·The Journal of Hand Surgery·Andrew Y ZhangJames Chang
Oct 24, 2007·The Journal of Hand Surgery, European Volume·M BerglundM Wiig
Nov 19, 2003·Clinics in Plastic Surgery·Andrew Y Zhang, James Chang
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Dec 4, 2003·The Journal of Hand Surgery·Richard K HarrisonDuncan Angus McGrouther
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael A Conlon, Frank M Tomas
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Feb 23, 2013·International Journal of Molecular Sciences·Hongjiang RuanCunyi Fan
Dec 3, 2013·Hand : Official Journal of the American Association for Hand Surgery·Masanori HayashiPeter C Amadio
Feb 14, 2012·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Roslyn B Evans
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Asheesh BediJoshua S Dines
Jun 15, 2010·The Journal of Hand Surgery·Jun IkedaPeter C Amadio
Jun 13, 2015·The Knee·Mustafa UsluHayati Kandiş
May 8, 2007·The Journal of Hand Surgery·Gil S KrygerJames Chang
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Jul 14, 2004·The Journal of Hand Surgery·Charles Hsu, James Chang
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Sep 5, 2003·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·R RagoowansiD A McGrouther
Sep 24, 2004·Annals of Plastic Surgery·Tetsu TsuboneKai-Nan An
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May 15, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Meng-Yi ChenPeter C Amadio
Sep 25, 2018·Acta orthopaedica et traumatologica turcica·Halil Can GemalmazSena Silay
Feb 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Meng-Yi ChenPeter C Amadio
Apr 3, 2003·The Journal of Hand Surgery·Martin E JonesD Angus McGrouther
Sep 8, 2020·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Yukihiro OsanamiEiichi Uchiyama

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