Differences in rates of diarrhea in patients with human immunodeficiency virus receiving lopinavir-ritonavir or nelfinavir

Pharmacotherapy
Jodie L GuestDavid Rimland

Abstract

To determine and compare rates of diarrhea in patients receiving an antiretroviral regimen containing lopinavir-ritonavir versus nelfinavir and in patients who received these drugs sequentially. Retrospective cohort analysis. Hospital-based human immunodeficiency virus (HIV) clinic. Four hundred one participants in the HIV Atlanta VA Cohort Study who were prescribed lopinavir-ritonavir or nelfinavir from 1996-2002. Chart review identified episodes of diarrhea that potentially were associated with an antiretroviral agent. Data collected included antidiarrheal agents dispensed, baseline viral load and CD4+ cell counts, demographic variables, and previous therapy Diarrhea associated with an antiretroviral regimen occurred in 175 (49%) of 354 patients receiving nelfinavir and 17 (17%) of 99 patients receiving lopinavir-ritonavir (p < 0.001). Treatment for the diarrhea occurred in 118 (33%) of 354 patients receiving nelfinavir and 9 (9%) of 99 receiving lopinavir-ritonavir (p < 0.001). Patients in the lopinavir-ritonavir group were more likely to have received highly active antiretroviral therapy and azithromycin than patients receiving nelfinavir, and they had lower baseline CD4+ cell counts (p < or = 0.01 for each comparison). The...Continue Reading

References

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Citations

Jan 18, 2006·Digestive Diseases and Sciences·Maribel Rodríguez-TorresAcisclo M Marxuach-Cuétara
Mar 7, 2009·World Journal of Gastroenterology : WJG·Ana Luiza Werneck-Silva, Ivete Bedin Prado
Dec 4, 2008·Digestive Diseases and Sciences·Chris N ConteasHardeep M Singh
Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·Montserrat Olmo, Daniel Podzamczer
Apr 24, 2010·Emergency Medicine Clinics of North America·George W Beatty
Aug 2, 2006·Gastroenterology Clinics of North America·Richard Goodgame
Jul 10, 2009·The American Journal of Clinical Nutrition·Pascal CrennJean Claude Melchior
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Chukwuemeka E Nwachukwu, Joseph U Okebe
Oct 18, 2005·Drugs·Caroline M PerryRisto S Cvetković

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