Differences in Real-World Health and Economic Outcomes Among Patients with COPD Treated with Combination Tiotropium/Olodaterol Versus Triple Therapy.

Journal of Managed Care & Specialty Pharmacy
Swetha R PalliJessica Franchino-Elder

Abstract

The 2018 Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends combination long-acting muscarinic antagonists/long-acting beta2-agonists (LAMA + LABA) as preferred maintenance therapy for patients with symptomatic chronic obstructive lung disease (COPD) after monotherapy and stepping up to triple therapy (TT; LAMA + LABA + inhaled corticosteroids [ICS]) in case of further exacerbations. Restrictions on TT recommendations have primarily been driven by higher pneumonia risk associated with regular ICS use. Evidence suggests that TT is overprescribed, which may affect economic and clinical outcomes. To compare health plan-paid costs, COPD exacerbations, and pneumonia diagnoses among patients newly treated with a LAMA + LABA regimen composed of tiotropium (TIO) + olodaterol (OLO) in a fixed-dose combination inhaler (TIO + OLO) or TT in a U.S. Medicare Advantage Part D insured population. This retrospective study identified COPD patients aged ≥ 40 years who were initiating TIO + OLO or TT (index regimen) between January 1, 2014, and March 31, 2018, from a national administrative claims database. Continuous insurance coverage for 12 months pretreatment (baseline) and ≥ 30 days posttreatment (follow-up) was required...Continue Reading

References

Mar 7, 2006·Thorax·E Sapey, R A Stockley
Apr 14, 2006·The European Respiratory Journal·M I RestrepoA Anzueto
Oct 18, 2011·Respiratory Medicine·Xavier PerezIan M Kronish
Jul 10, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Barbara P YawnKristijan H Kahler
Jul 31, 2014·ClinicoEconomics and Outcomes Research : CEOR·Junji LinKristijan H Kahler
Oct 18, 2014·The European Respiratory Journal·Dave SinghUNKNOWN ECLIPSE investigators
Jan 16, 2016·Therapeutic Advances in Chronic Disease·Leena George, Christopher E Brightling
Nov 2, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Donald P Tashkin
Mar 28, 2016·Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation·Suchit D KumbhareCharlie Strange
May 23, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Alejandro CasasMarc Miravitlles
Sep 11, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Roland BuhlHeinrich Worth
Sep 15, 2018·Annals of the American Thoracic Society·Sohini GhoshUNKNOWN Current and former investigators of the SPIROMICS sites and reading centers
Jul 16, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Charlie StrangeEric Wittbrodt
Apr 11, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Fabian A GreweMalcolm Kohler

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Citations

May 1, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Kartik Deshmukh, Arjun Khanna
May 15, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Leah B SansburySarah H Landis
Mar 26, 2021·Journal of Managed Care & Specialty Pharmacy·Swetha R PalliLindsay G S Bengtson

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