Differences in response of acetylcholinesterase to diisopropylfluorophosphate in the mesencephalic raphe region. A microelectrophoretic, histochemical, and biochemical study in albino rats

Acta histochemica
J SeidelM Müller

Abstract

To demonstrate the DFP-effects on the AChE of the mesencephalic raphe region albino rats were investigated using the pharmaco-histochemical method of Butcher et al. (1975). At several times after 1 mg DFP/kg body weight, the histochemical reactions in certain AChE-containing neurons were measured semiquantitatively and compared with biochemical data. Additionally, the multiple forms of water-soluble AChE were separated by microelectrophoresis. Only the electrophoretical results indicate changes of the structural AChE composition 5 d after DFP administration.

References

Jan 1, 1979·Journal of Neural Transmission·R C Meibach, L M Weaver
Jan 1, 1975·Journal of Neural Transmission·L L ButcherL Bilezikjian
Jun 1, 1986·Metabolic Brain Disease·A L Miller, M A Medina
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·A SmolenA C Collins
Oct 19, 1968·Nature·G A Davis, B W Agranoff
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Dec 1, 1996·The International Journal of Neuroscience·A TaglioniV Monaco

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