PMID: 6971194Jan 1, 1981Paper

Differences in response to anti-IgE and to anti-IgG in basophils from patients with bronchial asthma

Clinical Allergy
I KimuraK Takahashi

Abstract

Peripheral blood basophils of thirty-eight patients with bronchial asthma were examined for their reactivity to anti-IgE and anti-IgG antisera. Basophils of patients with serum IgE levels of more than 1001 i.u./ml reacted strongly to anti-IgE. Basophils of patients with serum IgE levels of less than 100 i.u./ml had a tendency to react more strongly to anti-IgG. An index (basophil ratio) was devised to compare the patient basophil reactivity to anti-IgE and anti-IgG. This basophil ratio was lower (IgE dominant) in the atopic cases which usually exhibited a high serum IgE level. Most cases with low serum IgE exhibited a high basophil ratio (IgG dominant). The basophils of seven intractable patients reacted more strongly to anti-IgG than to anti-IgE regardless of the serum IgE level.

References

Jan 1, 1973·International Archives of Allergy and Applied Immunology·A MalleyG Crossley
Jun 1, 1973·Clinical Allergy·I KimuraY Tanizaki
May 1, 1966·The Journal of Experimental Medicine·R T ReidR S Farr
May 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·A Malley, F Perlman
Dec 8, 1973·British Medical Journal·D H BryantL Lazarus

❮ Previous
Next ❯

Citations

Jun 4, 1993·Journal of Immunological Methods·K TakahashiI Kimura
Jun 23, 1993·Annals of the New York Academy of Sciences·I Kimura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.