Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle

PloS One
Samaneh ChaychiPierre Lachapelle

Abstract

Biological sex and age are considered as two important factors that may influence the function and structure of the retina, an effect that might be governed by sexual hormones such as estrogen. The purpose of this study was to delineate the influence that biological sex and age exert on the retinal function and structure of rodents and also clarify the effect that the estrus cycle might exert on the retinal function of female rats. The retinal function of 50 normal male and female albino Sprague-Dawley (SD) rats was investigated with the electroretinogram (ERG) at postnatal day (P) 30, 60, 100, 200, and 300 (n = 5-6 male and female rats/age). Following the ERG recording sessions, retinal histology was performed in both sexes. In parallel, the retinal function of premenopausal and menopausal female rats aged P540 were also compared. Sex and age-related changes in retinal structure and function were observed in our animal model. However, irrespective of age, no significant difference was observed in ERG and retinal histology obtained from male and female rats. Notwithstanding the above we did however notice that between P60 and P200 there was a gradual increase in ERG amplitudes of female rats compared to males. Furthermore, the ...Continue Reading

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Citations

Oct 29, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Samaneh ChaychiPierre Lachapelle
Aug 4, 2019·Molecular Neurobiology·María Florencia González FleitasRuth E Rosenstein
Oct 3, 2017·Journal of Huntington's Disease·Jocelynn R PearlSuman Jayadev
Oct 7, 2019·Journal of Neurochemistry·María F González FleitasRuth E Rosenstein
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Nov 12, 2019·Schizophrenia Research·Steven M SilversteinDocia L Demmin
Sep 7, 2021·Frontiers in Behavioral Neuroscience·Eric ArsenaultBenoit Labonté
Oct 14, 2021·Investigative Ophthalmology & Visual Science·Maria J RodrigoElena Garcia-Martin

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