Differences in risk factors for dementia with neurodegenerative traits and for vascular dementia

Dementia and Geriatric Cognitive Disorders
H WehrD Ryglewicz

Abstract

In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E (ApoE), low-density-lipoprotein (LDL)-receptor-related protein, alpha(2)-macroglobulin, interleukin (IL) 1beta, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In plasma, antibodies against Chlamydia pneumoniae and lipids were determined. Dementia was classified as probable Alzheimer's disease (AD), probable dementia of vascular origin (VaD) and mixed dementia (MD). An association of the disease with ApoE and IL-1beta polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD.

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Citations

Jun 3, 2009·Alzheimer Disease and Associated Disorders·James A MortimerWilliam R Markesbery
Jun 15, 2011·The International Journal of Neuroscience·Ye HuaMin Ye
May 6, 2010·Journal of the Neurological Sciences·Hua LiuRuo-Wei Liu
Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Jia-Hao SunJin-Tai Yu
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Suk Ling Ma, Linda Chiu Wa Lam
Apr 1, 2016·Journal of Alzheimer's Disease : JAD·Qingting HuNaidong Wang
Dec 17, 2008·Journal of Geriatric Psychiatry and Neurology·Hua LiuYi Wang
Oct 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Hee-Ju KangJin-Sang Yoon

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