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Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

bioRxiv

May 21, 2014

Edward C Stites

Abstract

Emerging data suggest different activating Ras mutants may have different biological behaviors. The most striking example may be in colon cancer, where activating KRAS mutations generally indicate a lack of benefit to treatment with EGFR inhibitors, although the activating KRAS G13D mut...read more

Mentioned in this Paper

Epidermal growth factor receptor inhibitor
Metabolic Inhibition
N-ras Gene Mutation
Ras Signaling Pathway
Evaluation
KRAS gene
K-ras Oncogene
Mutant Proteins
Mutation Abnormality
Inhibitors
1
7
Paper Details
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Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

bioRxiv

May 21, 2014

Edward C Stites

PMID: 990005397

DOI: 10.1101/005397

Abstract

Emerging data suggest different activating Ras mutants may have different biological behaviors. The most striking example may be in colon cancer, where activating KRAS mutations generally indicate a lack of benefit to treatment with EGFR inhibitors, although the activating KRAS G13D mut...read more

Mentioned in this Paper

Epidermal growth factor receptor inhibitor
Metabolic Inhibition
N-ras Gene Mutation
Ras Signaling Pathway
Evaluation
KRAS gene
K-ras Oncogene
Mutant Proteins
Mutation Abnormality
Inhibitors
1
7
Paper Details
References
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  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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