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Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

bioRxiv

May 21, 2014

Edward C. Stites

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Abstract

Emerging data suggest different activating Ras mutants may have different biological behaviors. The most striking example may be in colon cancer, where activating KRAS mutations generally indicate a lack of benefit to treatment with EGFR inhibitors, although the activating KRAS G13D mut...read more

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Kras NP_004976.2: p.G12V
Kras NP_004976.2: p.G12D
Mutant
Kras NP_004976.2: p.G13D
Evaluation
Gene Mutant
Mutant Proteins
Mutation Abnormality
N-ras Gene Mutation
Ras Signaling Pathway
1
7
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  • Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

    bioRxiv

    May 21, 2014

    Edward C. Stites

    PMID: 990005397

    DOI: 10.1101/005397

    Abstract

    Emerging data suggest different activating Ras mutants may have different biological behaviors. The most striking example may be in colon cancer, where activating KRAS mutations generally indicate a lack of benefit to treatment with EGFR inhibitors, although the activating KRAS G13D mut...read more

    Mentioned in this Paper

    Kras NP_004976.2: p.G12V
    Kras NP_004976.2: p.G12D
    Mutant
    Kras NP_004976.2: p.G13D
    Evaluation
    1
    7
    Paper Details
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      We're still populating references for this paper, please check back later.
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