PMID: 7336168Oct 1, 1981Paper

Differences in specific antibody responses of human tonsillar cells to an oral and a parenteral antigen

Scandinavian Journal of Immunology
R Paganelli, R J Levinsky

Abstract

Tonsillar lymphocytes stimulated in vitro with either beta-lactoglobulin or with tetanus toxoid were shown to produce specific antibodies by a direct plaque assay and by radioimmunoprecipitation of the culture supernatants. There was a sixfold increase in the number of IgA-secreting cells in response to beta-lactoglobulin; no such effect was seen in response to tetanus toxoid, where a fivefold rise in IgG-secreting cells occurred. These differences in antibody response are probably due to the route of initial antigen presentation. Those antigens priming the mucosa-associated lymphoid system stimulate mainly IgA-producing cells, in contrast to parenteral antigens, which elicit a predominantly IgM and IgG response.

References

Mar 1, 1979·The Journal of Experimental Medicine·C O ElsonW Strober
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Mar 1, 1979·Behavioral and Neural Biology·M A Persinger
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Sep 1, 1980·The Journal of Experimental Medicine·J A MattinglyC A Janeway

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Citations

Jan 1, 1990·International Journal of Immunopharmacology·G C FaureA Quantain
Mar 1, 1989·American Journal of Otolaryngology·Y HarabuchiA Kataura
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S SuzukiF Gejyo
Feb 1, 1985·The Proceedings of the Nutrition Society·R J Levinsky

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