PMID: 3757486Jan 1, 1986Paper

Differences in steroid metabolism by testis, prostate and epididymis in the immature and adult possum (Trichosurus vulpecula)

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
M Weiss

Abstract

Immature possums 126-195 days old and adults over 1 year old were used. Testicular homogenates from immature possums converted [3H]progesterone to nine different products, of which greater than 63% were 5 alpha-reduced androstane metabolites. The major product from adult testis was testosterone in yields greater than 60%. While metabolism of [3H]testosterone by the epididymis of immature possum was minimal, in adults 5 alpha-reduced products constituted greater than 80% of the yield. In contrast, prostatic tissue from adults converted less than 4% of [3H]testosterone to 5 alpha-reduced products, while the yields were greater than 80% from prostates of immature animals. The results showed that like in rodents, the testis of immature possum has a high 5 alpha-reductase and low 17 beta-hydroxysteroid dehydrogenase activity, which reverses in the adult state. The implications of the findings are discussed.

References

Jul 1, 1978·Journal of Reproduction and Fertility·B CookW R Gibson
Sep 1, 1975·Journal of Steroid Biochemistry·R F MorfinH H Floch
Apr 1, 1985·The Journal of Endocrinology·J D Curlewis, G M Stone
Sep 1, 1966·Endocrinology·H Inano, B I Tamaoki
Aug 1, 1980·Journal of Steroid Biochemistry·J P Preslock

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Citations

Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Weiss
May 24, 2001·Proceedings. Biological Sciences·Y Yom-Tov

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