Differences in subclinical cardiovascular disease between African American and Caucasian women with systemic lupus erythematosus.

Translational Research : the Journal of Laboratory and Clinical Medicine
Elisa Y RhewR Ramsey-Goldman

Abstract

Racial differences exist in disease rates and mortality in both cardiovascular disease (CVD) and systemic lupus erythematosus (SLE). The objective of this cross-sectional study was to compare the frequency and risk factors for subclinical CVD in African American (AA) and Caucasian women with SLE and no prior CVD events. Traditional CVD risk factors and SLE-related factors were assessed in 309 SLE women. Subclinical CVD was assessed by carotid ultrasound to measure intimamedial thickness (IMT) and plaque, and electron beam computed tomography (EBCT) was used to measure coronary artery calcium (CAC). AA women had less education and higher levels of body mass index, blood pressure, lipoprotein(a), C-reactive protein (CRP), fibrinogen, and erythrocyte sedimentation rate (ESR). However, AA women had lower albumin, more and longer duration of corticosteroid use, higher SLE disease activity and damage, and more dsDNA antibodies compared with Caucasian women after adjustment for age and study site. More AA women had carotid plaque (adjusted odds ratio [OR], 1.94; 95% confidence interval [CI], 1.03-3.65) and higher carotid IMT (0.620 vs 0.605 mm, P = 0.07) but similar CAC compared with Caucasians. A multivariate analysis revealed that t...Continue Reading

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Citations

Mar 19, 2013·Journal of Translational Medicine·Jane F FergusonMuredach P Reilly
Jul 15, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Mariana J Kaplan
Jul 15, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joseph AhearnSusan Manzi
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May 24, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine QuinlanKjell Tullus
Jul 8, 2016·PloS One·Suella MartinoUNKNOWN French Reference Center for Thrombotic Microangiopathies
Sep 4, 2019·Lupus Science & Medicine·S Sam LimCristina Drenkard
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Jun 13, 2020·Seminars in Arthritis and Rheumatism·Shiva GanjaliAmirhossein Sahebkar
Nov 7, 2021·The British Journal of Ophthalmology·Grace M RichterAmir H Kashani

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