Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts

Chemical Research in Toxicology
Belem Yoval-Sánchez, Jose S Rodríguez-Zavala

Abstract

Aldehyde dehydrogenases (ALDHs) are involved in the detoxification of aldehydes generated as byproducts of lipid peroxidation. In this work, it was determined that, among the three most studied human ALDH isoforms, ALDH2 showed the highest catalytic efficiency for oxidation of acrolein, 4-hydroxy-2-nonenal (4-HNE), and malondialdehyde. ALDH1A1 also exhibited significant activity with these substrates, whereas ALDH3A1 only showed activity with 4-HNE. ALDH2 was also the most sensitive isoform to irreversible inactivation by these compounds. Remarkably, ALDH3A1 was insensitive to these aldehydes even at concentrations as high as 20 mM. Formation of adducts of ALDH1A1 and ALDH2 with acrolein increased their K(d) values for NAD(+) by 2- and 3-fold, respectively. NADH exerted a higher protection than propionaldehyde to the inactivation by acrolein, and this protection was additive. These results suggested that both binding sites, those for aldehyde and NAD(+) in ALDH2, are targets for the inactivation by lipid peroxidation products. Thus, with the advantage of being relatively inactivation-insensitive, ALDH1A1 and ALDH3A1 may be actively participating in the detoxification of these aldehydes in the cells.

References

Mar 1, 1996·The Journal of Biological Chemistry·J S BoeschR G Lindahl
Mar 7, 1998·European Journal of Biochemistry·A YoshidaC Chang
Jul 11, 2001·Journal of Neuropathology and Experimental Neurology·M J PickloT J Montine
Jun 26, 2002·Biochemistry·Jose S Rodriguez-Zavala, Henry Weiner
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Nov 20, 2002·Chemical Research in Toxicology·Jonathan A Doorn, Dennis R Petersen
Jan 16, 2003·Biochimica Et Biophysica Acta·Ethan Nguyen, Matthew J Picklo
Apr 4, 2003·Japanese Journal of Clinical Oncology·Akira Yokoyama, Tai Omori
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·W J Burke
Jul 23, 2003·Journal of Neurochemistry·Tonya C MurphyMatthew J Picklo
Aug 20, 2004·The Journal of Biological Chemistry·Florian L MullerHolly Van Remmen
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Sanjeev ChoudharyNaseem H Ansari
Nov 5, 2005·Molecular Nutrition & Food Research·Gabriella LeonarduzziGiuseppe Poli
Jan 18, 2006·Chemical Research in Toxicology·Jonathan A DoornDennis R Petersen
Jun 27, 2006·Experimental Eye Research·Tia EsteyVasilis Vasiliou
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengMoon-shong Tang
Dec 13, 2006·The Journal of Biological Chemistry·Tia EsteyVasilis Vasiliou
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KochJ De Keyser
May 17, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne-Valerie CanteroAnne Nègre-Salvayre
Jan 26, 2008·Protein Science : a Publication of the Protein Society·José Salud Rodríguez-Zavala
Jan 26, 2008·Obesity Surgery·Stamatios LerakisRandolph P Martin
Sep 13, 2008·Science·Che-Hong ChenDaria Mochly-Rosen
Oct 14, 2008·Chemical Research in Toxicology·Olivier Falletti, Thierry Douki
Nov 22, 2008·Obesity·Francisco J TinahonesEduardo García-Fuentes
Jan 17, 2009·Chemical Research in Toxicology·Hsiang-Tsui WangMoon-Shong Tang
Feb 24, 2009·Chemical Research in Toxicology·Jian CaiWilliam M Pierce
Mar 3, 2009·Molecular Aspects of Medicine·Giuseppe PoliGabriella Leonarduzzi
Mar 20, 2009·Journal of Toxicology and Environmental Health. Part a·Tianlin XiaoNaseem H Ansari
Nov 6, 2009·Free Radical Research·Adriana Marquez-QuiñonesFrançoise Guéraud
Nov 17, 2009·Journal of Molecular and Cellular Cardiology·Grant R BudasDaria Mochly-Rosen
Jan 9, 2010·Methods in Molecular Biology·Rukhsana Sultana, D Allan Butterfield
Feb 18, 2010·Toxicology Mechanisms and Methods·Xing-yu LiuJian-ping Xie
Jun 19, 2010·Cardiovascular Research·Che-Hong ChenDaria Mochly-Rosen
Jul 17, 2010·Journal of Alzheimer's Disease : JAD·Manjeet SinghCharles Ramassamy
Mar 5, 2011·Atherosclerosis·Sanjay SrivastavaAruni Bhatnagar

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Citations

Oct 6, 2015·Biomolecules·Rudolf J SchaurPeter M Eckl
Oct 10, 2014·Journal of Neural Transmission·Edna Grünblatt, Peter Riederer
Nov 23, 2013·Parkinsonism & Related Disorders·Tanja Maria MichelPeter Riederer
Feb 28, 2013·Proteins·Belem Yoval-SánchezJose S Rodríguez-Zavala
Oct 31, 2014·Proteins·Javier A Belmont-DíazJosé S Rodríguez-Zavala
Jul 5, 2015·Biochemical Genetics·Qiao-Yan LiYu-Hua Qin
Oct 9, 2014·Annual Review of Pharmacology and Toxicology·Eric R GrossDaria Mochly-Rosen
Aug 16, 2016·The FEBS Journal·Javier A Belmont-DíazJosé S Rodríguez-Zavala
Feb 22, 2014·Chemical Research in Toxicology·Yohan D'SouzaBrian M Bennett
Oct 8, 2016·Environmental Health and Preventive Medicine·Akiko MatsumotoVasilis Vasiliou
Dec 3, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji MizunoHirofumi Yasue
Apr 9, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tomotaka UgaiKeitaro Matsuo
Dec 7, 2018·Chemistry : a European Journal·Raul PereiraTimothy H Witney
Feb 1, 2018·Molecular Genetics and Genomics : MGG·Fei WangQing Wang
Mar 26, 2019·Alcoholism, Clinical and Experimental Research·Tatiana L FonsecaAntonio C Bianco
Sep 24, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Amit R AgarwalEnrique Cadenas
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen
Feb 2, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Dec 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Adrien GuillotBin Gao
Jan 6, 2021·The FEBS Journal·Luis Francisco CallejaJosé Salud Rodríguez-Zavala
Nov 5, 2019·Biochimica Et Biophysica Acta. General Subjects·Luis Francisco CallejaJosé Salud Rodríguez-Zavala
Jan 2, 2020·ACS Central Science·Sebastiaan T A KoendersMario van der Stelt
Dec 24, 2019·Molecular Aspects of Medicine·Luiz H M BoziJulio C B Ferreira
Nov 26, 2020·Biomolecules·Moaddey AlfarhanS Priya Narayanan
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Qiaoling WangZhengsheng Zou
Jul 18, 2020·Biochimica Et Biophysica Acta. General Subjects·Belem Yoval-SánchezJosé Salud Rodríguez-Zavala
Jan 11, 2019·Chemical Research in Toxicology·José Salud Rodríguez-ZavalaBelem Yoval-Sánchez
Sep 19, 2018·Free Radical Biology & Medicine·Ligia Akemi KiyunaJulio Cesar Batista Ferreira

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