Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex.

British Journal of Pharmacology
S P AlexanderS J Hill

Abstract

1. 2-Chloroadenosine stimulated adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation and potentiated (guinea-pig) or inhibited (mouse) the histamine H1-receptor-stimulated hydrolysis of inositol phospholipids in slices of guinea-pig and mouse cerebral cortex. 2. Two xanthine-based adenosine receptor antagonists were identified which were one order of magnitude more potent at the adenosine receptor mediating augmentation of the histamine-stimulated inositol phospholipid hydrolysis than at the receptor linked to cyclic AMP formation in guinea-pig cerebral cortical slices. 3. These compounds, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) and 7-benzyl-3-(2-methylpropyl)xanthine (BMPX) retained their selectivity under near-identical incubation conditions in both assays. 4. These compounds also showed similar affinities and selectivity for the adenosine receptor mediating inhibition of histamine-stimulated inositol phospholipid hydrolysis in mouse cerebral cortical slices. 5. Inclusion of agents which give rise to, or mimic, high levels of cyclic AMP (forskolin (1 microM), 8-bromo-cyclic AMP (1 mM) and vasoactive intestinal polypeptide (1 microM] in the incubation medium failed to mimic the action of 2-chloroadenosine on inosi...Continue Reading

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Citations

Nov 1, 1994·Agents and Actions·D L Marquardt, L L Walker
Jun 1, 1993·British Journal of Pharmacology·J C OliveiraJ A Ribeiro
Nov 1, 1993·British Journal of Pharmacology·F HernándezS P Alexander
Jan 1, 1994·British Journal of Pharmacology·M C Peakman, S J Hill
Sep 1, 1994·British Journal of Pharmacology·F HernándezD A Kendall
Jul 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M C MichoudJ G Martin
Aug 28, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D L Picanço-DinizJ Antunes-Rodrigues
Jul 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·F N Ko
Jan 1, 1992·Journal of Neurochemistry·S K FisherB W Agranoff
Sep 19, 2007·British Journal of Pharmacology·S P H Alexander, D A Kendall
Aug 31, 1992·Biochemical and Biophysical Research Communications·K D PierceJ Shine

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