Differences in the aggressiveness of prostate cancer among Korean, Caucasian, and African American men: A retrospective cohort study of radical prostatectomy

Urologic Oncology
In Gab JeongJae Y Ro

Abstract

We aimed to compare the pathologic aggressiveness of clinically localized prostate cancer (PCa) treated by radical prostatectomy in Korean and Western (Caucasian and African American [AA]) men by analyzing data from representative hospitals in the capitals of Korea (Seoul) and the United States (Washington, DC). We performed a retrospective cohort study of 1,939 patients who underwent radical prostatectomy for clinically localized PCa in the Asan Medical Center and Washington Hospital Center. After adjusting for confounding clinical variables, we used multivariate logistic regression analysis to assess differences in the aggressiveness of PCa. We analyzed 1,152 Korean, 473 Caucasian, and 314 AA patients. There were significant differences between Korean and Western patients in terms of age at surgery, preoperative levels of prostate-specific antigen, and clinical stage (P<0.001). Overall, high-grade PCa (Gleason score≥8) was more common in Korean (19.4%) than in AA (6.1%) or Caucasian (5.5%) patients (P<0.001). The incidence of advanced-stage PCa (pT3 or higher) was higher in Korean (34.8%) than in AA (18.2%) or Caucasian (13.3%) patients (P<0.001). After adjusting for age, prostate-specific antigen, prostate volume, and clinic...Continue Reading

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Citations

Sep 24, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jae Young JoungYoung-Joo Won
Dec 23, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung Han KimKang Hyun Lee
Apr 20, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Chang Wook JeongHyung Jin Kim
Jan 27, 2017·Asia-Pacific Journal of Clinical Oncology·Natsuo TomitaTakeshi Kodaira
Jun 2, 2018·Chonnam Medical Journal·Sun-Seog Kweon
Oct 22, 2020·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Shanky SinghGagan Gautam
Dec 2, 2020·Investigative and Clinical Urology·Sang Hun SongSeok Soo Byun
Jan 6, 2021·World Journal of Surgical Oncology·Mahmoud MustafaYazan Eiss
May 5, 2021·Investigative and Clinical Urology·Sang Hun Song, Seok Soo Byun

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