Differences in the apoptosis-inducing properties of Viscum album L. extracts

Anti-cancer Drugs
A BüssingK Schweizer

Abstract

Viscum album L. (mistletoe) extracts are widely used in adjuvant cancer therapy. In contrast to purified components, such as mistletoe lectins and viscotoxins, whole plant extracts of mistletoe resulted in DNA stabilizations in cyclophosphamide-treated lymphocytes but also provided cytotoxicity in tumour cells and lymphocytes. The killing capacities of mistletoe extracts were host tree-specific and not correlated with mistletoe lectin or viscotoxin content. In human lymphocytes, only mistletoe lectins induced a pathway of apoptotic killing. Within 72 h, the lectin B chains also increased the number of lymphocytes undergoing apoptosis. This finding suggests that inhibition of protein synthesis by the A chain of the hololectin may accelerate a receptor-mediated killing pathway induced by the B chains. An unexpected finding was related to the mistletoe-mediated killing, which was more effective against CD8+T cells with an activated phenotype than CD19+ B cells and CD4+ T cells. In vitro treatment of human neutrophils with mistletoe resulted in a slight decrease of phagocytosis and burst activity. The observed dose-dependent occurrence of two neutrophil subsets with different burst activities indicates differences in their suscepti...Continue Reading

Citations

Aug 15, 1998·Journal of Ethnopharmacology·E YesiladaY Ono
Jul 13, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Arndt BüssingThomas Ostermann
Nov 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Oliver PodlechUlrike Naumann
Sep 14, 2012·Oncology Reports·Yu-Kyoung ParkByeong-Churl Jang
Apr 29, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Roland WackerWolfgang Voelter
Jul 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chaitrali SahaSrini V Kaveri
Jul 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Sonja SchötterlUlrike Naumann

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis