Differences in the clinical characteristics of Pneumocystis jirovecii pneumonia in immunocompromized patients with and without HIV infection

Respirology : Official Journal of the Asian Pacific Society of Respirology
Tatsuji EnomotoSeiichi Nakamura

Abstract

The incidence of Pneumocystis jirovecii pneumonia (PCP) in patients with predisposing immunodeficiencies other than AIDS is growing. Knowing the different characteristics and outcomes of PCP according to HIV status would help physicians manage and treat patients with PCP. The medical charts of all patients with a proven first episode of PCP, diagnosed between 1997 and 2007 were retrospectively reviewed, and clinical and laboratory data abstracted. Of the 35 patients with PCP, 18 were HIV-positive and 17 were HIV-negative with other immunosuppressive conditions. HIV-negative patients were significantly older than HIV-positive patients. The WCC (10 952 +/- 5669 vs 9750 +/- 3133/microL; P = 0.015), neutrophil counts (9631 +/- 5421 vs 5680 +/- 2628/microL; P = 0.01) and CD4+ lymphocyte counts (329 +/- 502 vs 47 +/- 50/microL; P < 0.001) were significantly higher in HIV-negative patients. Six of the 17 HIV-negative patients had a CD4+ lymphocyte count >300/microL. Serum IgG levels were lower in HIV-negative patients (943 +/- 379 vs 1635 +/- 657 mg/dL; P = 0.017). Mortality was higher in HIV-negative (52.9%) than in HIV-positive patients (0%). On univariate analysis, risk factors for mortality from PCP were the presence of underlying...Continue Reading

References

Dec 29, 1977·The New England Journal of Medicine·W T HughesS L George
Feb 1, 1985·The Journal of Clinical Investigation·T R CuppsA S Fauci
Dec 15, 1993·Annals of Internal Medicine·D T BoumpasJ E Balow
Feb 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S VidalE J Calderón
Feb 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Xavier MonnetChristian Richard
Mar 28, 2008·Seminars in Respiratory and Critical Care Medicine·Laurie C D'AvignonDuane R Hospenthal
Oct 31, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jang-Jih Lu, Chao-Hung Lee

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Citations

Jul 28, 2011·The Journal of Infectious Diseases·Xavier IriartAntoine Berry
Apr 25, 2012·Japanese Journal of Clinical Oncology·Hiroki HayashiAkihiko Gemma
Oct 12, 2011·Current Opinion in Infectious Diseases·Alistair B ReidLeon J Worth
Feb 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chi Chiu LeungStephen G Spiro
Mar 7, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Emilia HardakIlana Oren
Apr 12, 2012·Clinical Microbiology Reviews·Alison Morris, Karen A Norris
Feb 20, 2014·Enfermedades infecciosas y microbiología clínica·María Luisa AznarM Teresa Martín-Gómez
Oct 16, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ming-Chi LiWen-Chien Ko
Aug 29, 2012·Critical Reviews in Oncology/hematology·Filip Y De VosCarla M van Herpen
Jan 18, 2011·Arthritis Care & Research·Tanaz A KermaniKenneth J Warrington
Nov 6, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chia-Hao ChangChong-Jen Yu
Nov 6, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tatsuji EnomotoArata Azuma
Aug 7, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Sadatomo Tasaka, Hitoshi Tokuda
Mar 31, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yusuke AinodaKyoichi Totsuka
Oct 11, 2016·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Maria L Calero-BernalEva M Carmona
Feb 23, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yi LiValery Lavergne
Sep 24, 2015·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Shunsuke Mori, Mineharu Sugimoto
Apr 18, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Kazutoshi YukawaSeizo Yamana
Apr 12, 2020·Clinical Transplantation·Tilo FreiwaldIngeborg A Hauser
May 21, 2019·Current Opinion in Infectious Diseases·Hélène Guegan, Florence Robert-Gangneux
Mar 19, 2020·Tuberculosis and Respiratory Diseases·Sadatomo Tasaka
Jun 18, 2021·Respiratory Medicine·D WilmesN Kanaan
Jul 6, 2021·Frontiers in Public Health·Yuqiong WangQingyuan Zhan
Aug 27, 2021·Journal of Fungi·Eléna CharpentierXavier Iriart

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