Feb 1, 1977

Differences in the composition of the polypeptides deposited in the axon and the nerve terminals by fast axonal transport in the garfish olfactory nerve

Brain Research
P Cancalon, L M Beidler

Abstract

Proteins transported by the fast wave of axonal transport have been shown to be deposited both in the axon and in the nerve terminals. Differences in the nature of the molecules deposited in these two areas were studied in the garfish olfactory system. In order to avoid analysis of transported molecules in two different types of tissue like the olfactory nerve and the olfactory bulb, the study was conducted (1) by comparing the composition of the moving crest of radioactivity at two different points along the nerve: when the crest enters the axon and when it reaches a distance of approximatively 5 cm from the nerve endings, (2) by determining the composition of the molecules remaining in the axon behind the moving crest. Three subcellular fractions (two membranous fractions and a mitochondrial pellet) were investigated. In both membranous fractions the majority of the polypeptides deposited in the axon ranged from 50 to 150,000 daltons. No outstanding peak of radioactivity was found in either fraction. Radioactivity was relatively evenly distributed among the various polypeptides. In the lightest membranous fraction, however, a peak (mol. wt., 54-58,000) was more particularly deposited in the axon. The opposite situation was fo...Continue Reading

Mentioned in this Paper

Axonal Transport
Nerve Endings
Axon
Mitochondria
Polypeptides
Nerve Tissue Proteins
Olfactory Nerve

About this Paper

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