PMID: 9171942Jun 1, 1997Paper

Differences in the density of barosensitive neurons in the medulla of spontaneously hypertensive and Wistar-Kyoto rats

Clinical and Experimental Pharmacology & Physiology
Y XiongM Miura

Abstract

1. The density of barosensitive neurons in the medulla was examined in spontaneously hypertensive rats (SHR) and in normotensive Wistar-Kyoto (WKY) rats. In control experiments, rats were sham-operated, while in test experiments arterial baroreceptors were stimulated by pressor responses to i.v. administration of phenylephrine and the density of c-Fos-labelled neurons was immunocytologically examined. 2. In both control and test experiments, c-Fos-labelled neurons were distributed in cardiovascular control sites: the nucleus tractus solitarii (NTS) and the caudal and rostral ventrolateral medullas (CVLM/RVLM). 3. In both WKY rats and in SHR, the total density of labelled neurons in test experiments was significantly higher than in control experiments. 4. In control experiments, no significant difference was found in the distribution and density of labelled neurons in the NTS and in the CVLM/RVLM between rats and SHR. 5. In test experiments, no significant difference was found in the distribution and density of labelled neurons in the NTS between WKY rats and SHR. 6. In test experiments in SHR, the density of labelled neurons in the CVLM just caudal to the obex level was significantly higher than that in WKY rats, whereas the de...Continue Reading

References

Mar 1, 1991·Obstetrics and Gynecology·B B Little, L M Snell
Jul 1, 1969·The American Journal of Physiology·M Miura, D J Reis
Jun 1, 1981·Journal of the Autonomic Nervous System·J CirielloF R Calaresu
Dec 1, 1994·Journal of the Autonomic Nervous System·M MiuraJ Okada
Mar 19, 1993·Regulatory Peptides·G P AldredF A Mendelsohn

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Citations

Mar 9, 2002·Clinical and Experimental Hypertension : CHE·Abraham A Palmer, Morton P Printz
Aug 27, 2002·Journal of Hypertension·Paul M Pilowsky, Ann K Goodchild

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