Differences in the expression of the adenosine A1 receptor in adipose tissue of obese black and white women

The Journal of Clinical Endocrinology and Metabolism
Hisham BarakatMona M McConnaughey

Abstract

African-American women (AAW) lose less weight and at a slower rate than Caucasian women (CAW) under the same weight-loss regimens. A potential cause of this finding is inhibition of lipolysis. Because alpha-2 and adenosine receptors are directly involved in inhibition of lipolysis, differences in alpha-2 or adenosine A1 receptors in visceral adipose tissue (VAT) and sc adipose tissue (SAT) from obese AAW and CAW were determined. Measurements of maximal binding capacity (Bmax) of alpha-2 and adenosine A1 receptors as well as protein and mRNA levels of the adenosine receptor in VAT and SAT from AAW and CAW were taken. The study was conducted in the general community. Patients were selected by body mass index greater than 40 and age matched. Bmax (density) of the two receptors and protein and mRNA levels of adenosine receptors were determined in adipose tissue of AAW and CAW. No differences were found for alpha-2 receptor Bmax in either VAT or SAT from AAW and CAW. Bmax (but not the dissociation constant, Kd) for the adenosine A1 receptor in VAT from AAW was higher (P < 0.05) than in VAT from CAW. Adenosine receptor protein and mRNA levels were significantly higher in VAT from AAW than VAT from CAW. No racial differences in these ...Continue Reading

Citations

Jun 15, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D L FrankoP B Crawford
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Jun 15, 2013·Pharmacology & Therapeutics·John P HeadrickJason N Peart
Nov 14, 2008·International Journal of Cardiology·Pawan D PatelRohit R Arora
Aug 15, 2012·BioFactors·Andrea EscuderoCarlos Escudero
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Borzo GharibiBronwen A J Evans
Jun 15, 2011·Food Chemistry·Nancy Dewi YulianaRobert Verpoorte
Nov 26, 2010·Biochimica Et Biophysica Acta·John P HeadrickLuke J Haseler
Apr 6, 2018·Purinergic Signalling·Geoffrey Burnstock, Daniela Gentile
Sep 18, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Xueping ZhouS Jamal Mustafa
Aug 15, 2020·Frontiers in Immunology·Flaminia BardanzelluVassilios Fanos
Dec 29, 2020·Biochemical Pharmacology·Shanu Jain, Kenneth A Jacobson
May 18, 2021·Frontiers in Pharmacology·Vanni CarusoMaurizio Ronci
Jun 11, 2021·Expert Review of Proteomics·Flaminia BardanzelluVassilios Fanos
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.