PMID: 9529056Apr 7, 1998Paper

Differences in the frequency of cytokine-producing cells in antigenemic and nonantigenemic individuals with bancroftian filariasis

Infection and Immunity
A B de AlmeidaD O Freedman

Abstract

Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from a Wuchereria bancrofti-endemic area of Brazil were classified as being asymptomatic microfilaremic individuals, antigenemic individuals with clinical filariasis, or nonantigenemic individuals with clinical filariasis. Intracellular cytokine staining of mitogen-stimulated peripheral blood mononuclear cells (PBMC) showed that the frequency of either gamma interferon (IFN-gamma)- or interleukin-4 (IL-4)-producing cells was higher in the nonantigenemic individuals with clinical filariasis than in the asymptomatic microfilaremic individuals (geometric means, 22.1 versus 10.7% [P = 0.02] and 2.9 versus 1.4% [P = 0.01], respectively). When the asymptomatic microfilaremic individuals and antigenemic individuals with clinical filariasis were grouped together to constitute all actively infected individuals, the frequency of IFN-gamma-producing cells was also lower than in the nonantigenemic individuals with clinical filariasis (P = 0.04). Likewise, the frequency of IL-4-producing cells in the actively infected individuals was also lower than in the nonantigenemic individuals with clinical filariasis (P = 0.02). ...Continue Reading

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Citations

Dec 25, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·N O NielsenP E Simonsen
Sep 21, 2013·Lymphatic Research and Biology·Thomas B Nutman
Oct 12, 2012·Seminars in Immunopathology·Subash Babu, Thomas B Nutman
Nov 22, 2011·PLoS Neglected Tropical Diseases·Xiaoyun WenChuan Su
Sep 7, 2018·Parasite Immunology·Candace M de AndradeCamila A Figueiredo
Sep 15, 2000·Journal of Immunological Methods·P PalaP J Openshaw
Jan 5, 2000·Microbes and Infection·A B de Almeida, D O Freedman

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