Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population.

BMC Microbiology
Alexander VaisermanAlexander Koliada

Abstract

Gut microbiota plays an important role in physiological and pathological processes of the host organism, including aging. Microbiota composition was shown to vary significantly throughout the life course. Age-related changes in the composition of microbiota were reported in several human studies. In present study, age-related dynamics of phylogenetic profile of gut microbiota was investigated in 1550 healthy participants from Ukrainian population. Significant changes in the microbiota composition determined by qRT-PCR at the level of major microbial phyla across age groups have been observed. The relative abundance of Actinobacteria and Firmicutes phyla increased, while that of Bacteroidetes decreased from childhood to elderly age. Accordingly, the Firmicutes/Bacteroidetes (F/B) ratio was shown to significantly increase until elder age. In both sexes, odds to have F/B > 1 tended to increase with age, reaching maximum values in elder age groups [OR = 2.7 (95% CI, 1.2-6.0) and OR = 3.7 (95% CI, 1.4-9.6) for female and male 60-69-year age groups, respectively, compared to same-sex reference (0-9-year) age groups]. In conclusion, data from our study indicate that composition of the human intestinal microbiota at the level of major ...Continue Reading

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Citations

Jan 14, 2021·PloS One·Yee Teng LeeLoo Keat Wei
Jan 12, 2021·Expert Review of Clinical Immunology·Larissa Koidl, Eva Untersmayr
May 1, 2021·Journal of Personalized Medicine·Irina Grigor'evaMarsel Kabilov
May 2, 2021·BMC Microbiology·Alexander KoliadaAlexander Vaiserman
Aug 31, 2021·Gut Microbes·Kerstin SchüttePeter Malfertheiner

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Methods Mentioned

BETA
phylogenetic profile
PCR

Software Mentioned

MedCalc

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