The hemoglobins of man, horse, dog, rabbit, guinea pig, and rat all have relatively high (nonphysiologic) oxygen affinity when stripped of organic phosphates, and a strong reactivity with 2,3-diphosphoglycerate (2,3-DPG). Appropriately, their red cells contain high levels of 2,3-DPG. In contrast, the sheep, goat, cow, and cat have low oxygen affinity hemoglobins which interact weakly with 2,3-DPG, and low concentrations of red cell 2,3-DPG. These hemoglobins have structural differences at the NH(2)-terminus of the beta chain, a site where 2,3-DPG is thought to bind.
The phylogenetic distribution of red cell 2,3 diphosphoglycerate and its interaction with mammalian hemoglobins
Interaction of organic phosphates with bovine hemoglobin. II. Oxygen binding equilibria of newborn and adult hemoglobin
Redistribution of hydrogen ion and chloride, and water shift across the red cell membrane of human and ruminant blood with changes in oxygen saturation
Effect of oxygen saturation on H+ and Cl- distribution across the red cell membrane in human and ruminant blood
Effect of hemoglobin solution on the response of intracranial and subcutaneous 9L tumors to antitumor alkylating agents
Change in the content of ATP and 2,3-diphosphoglycerate in the erythrocytes of rats adapted to hypoxia
Effect of a bovine hemoglobin preparation on the response of the FSaIIC fibrosarcoma to chemotherapeutic alkylating agents
Changes in red cell 2,3-diphosphoglycerate concentration as cause of the postnatal decrease of pig blood oxygen affinity
Bovine hemoglobin as a potential source of hemoglobin-based oxygen carriers: crosslinking with bis(2,3-dibromosalycyl)fumarate
Oxygen transport and phosphorylated glycolytic intermediates of the ruminant blood--I. Sika deer (Cervus nippon nippon)
Metabolism of glycerate-2,3-P2--VII. Enzymes involved in the metabolism of glycerate-2,3-P2 in cat tissues
The chloride shift may facilitate oxygen loading and unloading to/from the hemoglobin from the brown bear (Ursus arctos L.)
Effects of intra- and intermolecular crosslinking on the free radical reactions of bovine hemoglobins
Functional characterisation of Eskimo dog hemoglobin: I. Interaction of Cl- and 2,3-DPG and its importance to oxygen unloading at low temperature
A comparative study on the functional properties of the wild European mouflon and domestic sheep hemoglobins
Low-temperature sensitivity and enhanced Bohr effect in red deer (Cervus elaphus) haemoglobin: a molecular adaptive strategy to life at high altitude and low temperature
Studies on the roles of apotransferrin and caeruloplasmin (EC 22.214.171.124) on iron absorption in copper-deficient rats using an isolated vascularly- and luminally-perfused intestinal preparation
Effects of ionic strength on the regulation of Na/H exchange and K-Cl cotransport in dog red blood cells
Crystallization of sheep (Ovis aries) and goat (Capra hircus) haemoglobins under unbuffered low-salt conditions
Purification, crystallization and preliminary crystallographic study of low oxygen-affinity haemoglobin from cat (Felis silvestris catus) in two different crystal forms
The X-ray structure determination of bovine carbonmonoxy hemoglobin at 2.1 A resoultion and its relationship to the quaternary structures of other hemoglobin crystal froms
Species differences in the binding of compounds designed to fit a site of known structure in adult human haemoglobin
Myocardial energy production and consumption remain balanced during positive inotropic stimulation when coronary flow is restricted to basal rates in rabbit heart
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
Structure of liganded T-state haemoglobin from cat (Felis silvestris catus), a low oxygen-affinity species, in two different crystal forms
Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin
The functional, oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity
Oxygen binding of fetal and adult bovine hemoglobin in the presence of organic phosphates and uric acid riboside
Effect of a bovine hemoglobin preparation (SBHS) on the response of two murine solid tumors to radiation therapy or chemotherapeutic alkylating agents
Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content
Effect of oxygen level on the enhancement of tumor response to radiation by perfluorochemical emulsions or a bovine hemoglobin preparation
Reaction of nitrite with human fetal oxyhemoglobin: a model simulation study with implications for blood flow regulation in sickle cell disease (SCD)
Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry
Structure and function of sheep hemoglobin Chios: A novel allele at the HBBB locus with two Lys-->Arg substitutions at positions beta66(E10) and beta144(HC1)
The adaptation of polar fishes to climatic changes: Structure, function and phylogeny of haemoglobin
Modulation of oxygen affinity in hemoglobin by solvent components. Interaction of bovine hemoglobin with 2,3-diphosphoglycerate and monatomic anions
Diphosphoglycerate mutase and 2,3-diphosphoglycerate phosphatase activities of red cells: comparative electrophoretic study
Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobins
Isovolemic hemodilution with a bovine hemoglobin-based oxygen carrier: effects on hemodynamics and oxygen transport in comparison with a nonoxygen-carrying volume substitute
Barbary sheep (Ammotragus lervia): the structure of the adult beta-globin gene and the functional properties of its hemoglobin
Relationship between the oxygen affinity and in vitro sickling propensity of carbamylated sickle erythrocytes
Functional characterization of fetal and adult yak hemoglobins: an oxygen binding cascade and its molecular basis
Effects of organic phosphates on oxygen equilibria and kinetics of -SH reaction in feline hemoglobins
The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution
Dose-dependent effects of Chlamydia psittaci infection on pulmonary gas exchange, innate immunity and acute-phase reaction in a bovine respiratory model
The Bohr effect of haemoglobin in vertebrates: an example of molecular adaptation to different physiological requirements
Regulation of erythrocyte function: Multiple evolutionary solutions for respiratory gas transport and its regulation in fish
Interaction of organic phosphates with bovine hemoglobin. I. Oxylabile and phosphate-labile proton binding
The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.
Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.
Genetic Screens in iPSC-derived Brain Cells
Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.
This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Pharmacology of Proteinopathies
This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.
Alignment-free Sequence Analysis Tools
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.