Differences in the Outcome of Patients with COPD according to Body Mass Index

Journal of Clinical Medicine
Zichen JiJulio Hernández-Vázquez

Abstract

In chronic obstructive pulmonary disease (COPD), the "obesity paradox" is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). An observational study with a six-year prospective follow-up of 273 COPD patients who attended a spirometry test in 2011. Survival and acute events were analyzed according to the BMI quartiles. A total of 273 patients were included. BMI quartiles were ≤24.23; 24.24-27.69; 27.70-31.25; ≥31.26. During the follow-up, 93 patients died. No differences were found in exacerbations, pneumonia, emergency visits, hospital admissions or income in a critical unit . Survival was lower in the quartile 1 of BMI with respect to each of the 2-4 quartiles (p-value 0.019, 0.013, and 0.004, respectively). Advanced age (hazard ratio, HR 1.06; 95% confidence interval, CI 1.03-1.09), low pulmonary function (HR 0.93; 95% CI 0.86-0.99), exacerbator with chronic bronchitis phenotype (HR 1.76; 95% CI 1.01-3.06), high Charlson (HR 1.32, 95% CI 1.18-1.49), and the quartile 1 of BMI (HR 1.99, 95% CI 1.08-3.69) were identified as risk factors independently associated with mortality. In COPD, low BMI conditions a lower survival, although not for ha...Continue Reading

References

Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·C LandboT P Almdal
Nov 8, 2008·Chest·Carl J LavieRichard V Milani
Oct 27, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Jordan A GuenetteDenis E O'Donnell
Dec 1, 2010·International Journal of General Medicine·Christopher ZammitHimender Makker
Feb 22, 2011·Archivos de bronconeumología·Javier de Miguel DíezLuis Puente Maestu
Feb 26, 2011·Journal of Applied Physiology·Josuel OraDenis E O'Donnell
Jul 19, 2011·Journal of Cachexia, Sarcopenia and Muscle·Mitja LainscakStanislav Suskovic
Apr 26, 2014·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·N Barbarito, E De Mattia
May 3, 2014·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Roxana G GalesanuFrançois Maltais
Jun 6, 2014·Mediators of Inflammation·Cheryl Wang
Sep 23, 2014·The European Respiratory Journal·Annemie M ScholsSally J Singh
Apr 12, 2016·Journal of Cachexia, Sarcopenia and Muscle·Karin J C SandersAnnemie M W J Schols
Feb 17, 2017·American Journal of Men's Health·Moloud PayabNooshin Shirzad
Oct 27, 2017·BMJ Open Respiratory Research·Eric AbstonMichael Eberlein
Nov 8, 2017·Eating and Weight Disorders : EWD·Francesco SpeltaM Ferrari
Feb 2, 2018·Annals of the American Thoracic Society·Anand S Iyer, Mark T Dransfield
Oct 22, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Kazuto MatsunagaAntonio Anzueto

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