PMID: 11334693May 4, 2001Paper

Differences in the pharmacodynamics of epinephrine and vasopressin during and after experimental cardiopulmonary resuscitation

Resuscitation
A NozariL Wiklund

Abstract

Vasopressin has been investigated as a possible alternative to epinephrine during cardiopulmonary resuscitation (CPR). We tested the hypothesis that vasopressin, in comparison with epinephrine, would improve cerebral blood flow and metabolism during CPR as well as after restoration of spontaneous circulation (ROSC). A total of 22 anaesthetised piglets were subjected to 5 min of ventricular fibrillation followed by 8 min of closed-chest CPR. The piglets were randomly allocated to receive repeated boluses of either 45 microg/kg epinephrine or 0.4 U/kg vasopressin IV. Haemodynamic parameters, cerebral cortical blood flow and cerebral tissue pH and PCO(2) were continuously monitored during CPR and up to 4 h after ROSC. Cerebral oxygen extraction ratio was calculated. Cerebral cortical blood flow increased transiently after each bolus of epinephrine, while only the first bolus of vasopressin resulted in a sustained increase. The peak in cerebral cortical blood flow was reached approximately 30 s later with vasopressin. During the initial 5 min following ROSC, cerebral cortical blood flow was greater in the vasopressin group. In conclusion, there is a difference between epinephrine and vasopressin in the time from injection to maxima...Continue Reading

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Oct 1, 1992·Anesthesiology·K H LindnerM Georgieff
Nov 1, 1990·Annals of Emergency Medicine·N A Paradis, E M Koscove
Aug 1, 1990·Journal of the American College of Cardiology·M G MideiA D Guerci
Jan 1, 1989·Intensive Care Medicine·K H LindnerI M Bowdler
Mar 1, 1989·Annals of Emergency Medicine·D W OlsonC Aprahamian
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U DirnaglW Pulsinelli
Jan 1, 1988·General Pharmacology·A W Fox
Mar 1, 1985·Resuscitation·L WiklundL Jorfeldt
Oct 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Oberg
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·Y SuzukiM Shibuya
Dec 1, 1993·Resuscitation·K A Hossmann
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M TakayasuH Hidaka
Jun 15, 1996·Annals of Internal Medicine·K H LindnerK G Lurie
Jul 1, 1996·Stroke; a Journal of Cerebral Circulation·A W PrengelA Keller
Jul 1, 1996·Journal of Accident & Emergency Medicine·T H Rainer, C E Robertson
Dec 30, 1999·Annals of Emergency Medicine·G Bar-JosephS Ben-Haim

❮ Previous
Next ❯

Citations

Nov 20, 2003·Resuscitation·Giuseppe G L Biondi-ZoccaiLuigi M Biasucci
Oct 19, 2002·Current Opinion in Critical Care·Jerry P NolanLeo L Bossaert
Aug 9, 2003·Acta Anaesthesiologica Scandinavica·X L LiuS Basu
Jan 16, 2019·Pediatric Pulmonology·Reem AmerShyamala Dakshinamurti
Aug 26, 2006·Anesthesiology·Tanja A Treschan, Jürgen Peters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.