Differences in the preferential location and invasiveness of diffuse low-grade gliomas and their impact on outcome.

Cancer Medicine
Francesco LatiniMats Ryttlefors

Abstract

Low-grade gliomas (LGGs) are primary diffuse slow-growing brain tumors derived from glial cells. The management of these tumors is dependent on their location, which often harbors eloquent areas. We retrospectively recorded the location of diffuse gliomas to identify whether specific differences exist between the histological types. We analyzed 102 patients with previous histological diagnosis of WHO-II astrocytomas (62) and WHO-II oligodendrogliomas (40) according to WHO-2016 classification. MRI sequences (T2-FLAIR) were used for tumor volume segmentation and to create a frequency map of their locations within the Montreal Neurological Institute (MNI) space. The Brain-Grid (BG) system (standardized radiological tool of intersected lines according to anatomical landmarks) was created and merged with a tractography atlas for infiltration analysis. Astrocytomas frequently infiltrated association and projection white matter pathways within fronto-temporo-insular regions on the left side. Oligodendrogliomas infiltrated larger white matter networks (association-commissural-projection) of the frontal lobe bilaterally. A critical number of infiltrated BG voxels (7 for astrocytomas, 10 for oligodendrogliomas) significantly predicted sh...Continue Reading

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Citations

Apr 4, 2021·Journal of Clinical Medicine·Francesco LatiniMats Ryttlefors
Oct 9, 2021·Frontiers in Oncology·Tomás Gómez VecchioAsgeir S Jakola

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Methods Mentioned

BETA
SMA
biopsy
surgical resection

Software Mentioned

‐ Grid
DSI studio
DSI
SPSS
Brain
Brain Grid
Vue picture archiving and communication system ( PACS )
Grid DTT
‐ Grid System

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