Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder

Psychoneuroendocrinology
C S de KloetH G M Westenberg

Abstract

Neuroendocrine studies have shown profound alterations in HPA-axis regulation in posttraumatic stress disorder (PTSD). Based on baseline assessments and the response to dexamethasone, a hypothalamic overdrive with enhanced glucocorticoid feedback inhibition has been suggested. The dexamethasone-corticotrophin releasing hormone (DEX-CRH) test has shown to be a more sensitive test to assess HPA-axis dysregulation in major depression and therefore may provide a useful test tool to probe HPA-axis regulation in PTSD. To evaluate the effect of PTSD on HPA-axis regulation, we compared the response to a DEX-CRH test between male veterans with PTSD (n=26) and male veterans, who had been exposed to similar traumatic events during their deployment, without PTSD (n=23). Patients and controls were matched on age, year and region of deployment. Additionally, we compared the response of PTSD patients with (n=13) and without co-morbid major depressive disorder (MDD) (n=13). No significant differences were observed in ACTH and cortisol response to the DEX-CRH test between patients and controls. PTSD patients with co-morbid MDD showed a significantly lower ACTH response compared to patients without co-morbid MDD. The response to the DEX-CRH test...Continue Reading

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Citations

Nov 20, 2009·Journal of Psychosomatic Obstetrics and Gynaecology·Katja WingenfeldChristine Heim
Jul 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Katja WingenfeldStefan Lautenbacher
Feb 27, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Katja GotovacDragan Dekaris
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Jun 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ozen Onen SertozHayriye Elbi Mete
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Dec 3, 2011·Psychoneuroendocrinology·Danka SavicGordana Matic
Dec 27, 2011·Psychoneuroendocrinology·Katja WingenfeldOliver Tobias Wolf
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