Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice

Vision Research
S YazullaL H Pinto

Abstract

Immunocytochemical methods were used to compare the GABA system in control mice and two mutant strains: spastic which has reduced glycine receptors and retinal degeneration mutant in which the photoreceptors degenerate and reportedly have increased GABA and GAD levels. We found that the spastic mutant retina had reduced GABA-immunoreactivity (IR) in the proximal retina, reduced staining for GAD-1440 in the OPL, and reduced GABAA receptor staining in the OPL, compared to control. The retinal degeneration mutant retinas had enhanced GABA-IR throughout the retina, particularly in Müller cells, bipolar cells and IPL, and enhancement of GABAA receptor staining in the OPL, compared to control. The distributions of GABA-IR, GAD-1440-IR and GABAA receptor-IR in retinas of spastic mutant mice that also expressed the retinal degeneration phenotype resembled those found in retinas of mice that expressed only the retinal degeneration phenotype rather than those that expressed only the spastic mutation. No differences were observed among the conditions for GAD-65, GAD-67 or GABA-T. Our results with the spastic and retinal degeneration mutant mice demonstrate that attenuation in the glycinergic system and photoreceptor degeneration, respecti...Continue Reading

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Citations

Feb 9, 2012·Visual Neuroscience·Chi Zhang, Maureen A McCall
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Strettoi, V Pignatelli
Apr 6, 2011·Visual Neuroscience·Eyal MargalitWallace B Thoreson
Jul 15, 2009·Neuropharmacology·Bing LangSanbing Shen
Dec 31, 2008·Neurochemistry International·Andreas BringmannAndreas Reichenbach
Dec 15, 2012·The Journal of Comparative Neurology·Riki GibsonMichael Kalloniatis
Mar 29, 2002·The Journal of Comparative Neurology·Juan G CuevaNicholas C Brecha
Feb 22, 2001·Experimental Eye Research·J C RenN S Peachey
May 26, 2006·Vision Research·Thomas M O'HearnMark S Humayun
Oct 20, 2005·Developmental Biology·Andrei AvanesovUNKNOWN Tuebingen 2000 Screening Consortium
Jul 13, 2000·Microscopy Research and Technique·E L Fletcher
Apr 22, 2008·The Journal of Comparative Neurology·Hong-Ping Xu, Ning Tian
Apr 24, 2019·Molecular Autism·Elisa Maria Guimarães-SouzaSilvana Chiavegatto
Dec 19, 2020·Frontiers in Cellular Neuroscience·Arlene A HiranoNicholas C Brecha

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