PMID: 8453324Jan 1, 1993Paper

Differences in the time course of the effects of oophorectomy in women on parameters of bone metabolism and interleukin-1 levels in the circulation

Bone and Mineral
C E FioreC Tamburino

Abstract

Interleukin-1 is a cytokine with bone-resorbing activity which is claimed to play a role in the pathogenesis of osteoporosis and of post-oophorectomy bone loss. We measured plasma levels of interleukin-1 (IL-1) in 16 women who underwent hysterectomy and bilateral oophorectomy and in 12 women with hysterectomy alone before surgery and 7, 15, 30, 45 and 60 days after surgery. Only oophorectomized patients showed a significant increase of circulating interleukin-1 levels. This increase was significant only 30 days after surgery, whereas a rise at 7 days (P < 0.001) was observed for serum calcium and hydroxyproline/creatinine and calcium/creatinine ratios. These data do not indicate a definite role of IL-1 in promoting bone resorption in estrogen-deficient women in vivo.

References

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Citations

Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W R McKaneB L Riggs
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Pacifici
Jan 7, 2004·Maturitas·Donna Kritz-SilversteinElizabeth Barrett-Connor
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S KokaR A Reinhardt
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R M ArisG E Lester
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C PriorL Atley
May 16, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S Disthabanchong, E A González
Jul 30, 2003·Journal of Dental Research·A Al-RasheedD N Tatakis
Oct 23, 1997·American Journal of Physical Anthropology·S R SaundersM A Katzenberg

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