Differences in the viral genome between HPV-positive cervical and oropharyngeal cancer

PloS One
Bailey A LeConteVicente A Resto

Abstract

Human papillomavirus (HPV)-driven oropharyngeal cancer incidence in the United States has steadily increased in the past decades and has now become the most frequently diagnosed HPV-associated cancer type, surpassing cervical cancer. Variations in the HPV genome correlate with tumorigenic risk, and the distribution of genetic variants is extensively studied in cervical cancer, but very little is known about new mutations or the distribution of HPV types and variants in oropharyngeal cancer. Here we present an archival tissue cohort study that compares genomic characteristics of HPV associated with cervical versus oropharyngeal tumors using DNA sequence analysis. We found HPV16 to be more prevalent in oropharyngeal samples than in cervical samples (91.2% versus 52.9%), while HPV18 (1.5% versus 18.2%) and HPV45 (0.7% versus 9.9%) were much less prevalent. Differences between cervix and oropharynx in HPV16 variants distribution were more subtle, but the combined European + Asian (EUR+AS) variant group was more prevalent (90.2% versus 71.4%), while the American Asian 1 + American Asian 2 (AA1+AA2) variant group was much less prevalent (4.4% versus 22.5%) in oropharyngeal cancers. HPV prevalence in oropharyngeal cancers showed an in...Continue Reading

References

Nov 1, 1966·Journal of Theoretical Biology·P H Sneath
Nov 12, 1998·Journal of the National Cancer Institute·S M SchwartzD A Galloway
Mar 10, 2001·The Journal of Pathology·A Giannoudis, C S Herrington
Oct 2, 2002·Journal of Molecular Evolution·Victor R DeFilippisLuis P Villarreal
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee R KreimerSilvia Franceschi
Jun 23, 2006·The New England Journal of Medicine·Rachel L WinerLaura A Koutsky
Nov 15, 2008·Virology·Margaret E McLaughlin-Drubin, Karl Münger
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Rosemary E ZunaTravis Teel
Oct 19, 2010·The Lancet Oncology·Silvia de SanjoseUNKNOWN Retrospective International Survey and HPV Time Trends Study Group
Apr 30, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jean Lacau St GuilyFrançois Denis
Jun 28, 2011·Molecular Cancer·Ingeborg ZehbeLevana Sherman
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Apr 12, 2012·Journal of Virology·Iris CornetUNKNOWN IARC HPV Variant Study Group
Dec 5, 2012·Vaccine·David FormanSilvia Franceschi
Apr 10, 2013·International Journal of Cancer. Journal International Du Cancer·Maura L GillisonSilvia Franceschi
May 29, 2013·Virology·Scott B Vande Pol, Aloysius J Klingelhutz
Jun 12, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Salvatore VaccarellaFreddie Bray
Sep 4, 2013·Virology·Robert D BurkZigui Chen
Jan 28, 2014·Oral Oncology·Kristen B PytyniaErich M Sturgis
May 1, 2015·Journal of the National Cancer Institute·Mona SaraiyaUNKNOWN HPV Typing of Cancers Workgroup
May 21, 2015·Infectious Agents and Cancer·Luc Magloire Anicet BoumbaMustapha Moulay Ennaji
Sep 16, 2015·Cancer Epidemiology·N J FarsiM-C Rousseau
Jan 21, 2016·Nature·Denise Martinez-ZapienKatia Zanier
Aug 6, 2017·Postgraduate Medical Journal·Ankit ShahPankaj Chaturvedi
Sep 9, 2017·Cell·Lisa MirabelloMark Schiffman

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Citations

Feb 6, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Shao H HuangBrian OʼSullivan
Jul 13, 2021·Frontiers in Molecular Biosciences·Shane BrennanOrla Sheils
Jul 17, 2021·Prostate Cancer and Prostatic Diseases·Juan Javier-DesLogesJ Kellogg Parsons
Aug 10, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Vuk BortnikAdi Idris
Aug 31, 2021·Seminars in Radiation Oncology·Brian T BeatyAshley A Weiner

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Methods Mentioned

BETA
PCR

Software Mentioned

Cn3D
Geneious
SAS

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