Differences in time from HIV seroconversion to CD4+ lymphocyte end-points and AIDS in cohorts of homosexual men

AIDS
P J VeugelersW Winkelstein

Abstract

To evaluate the decline in CD4+ counts in relation to the incidence of AIDS in different cohorts of homosexual men and to quantify possible consequences of laboratory variation in CD4+ measurement. Our study includes 403 men with well documented dates of HIV seroconversion originating from five cohort studies among homosexual men. Differences in time from HIV seroconversion to the first CD4+ count dropping < 500 or 200 x 10(6)/l and to AIDS were evaluated using Kaplan-Meier survival analyses. We found considerable differences between cohorts in CD4+ depletion, but not in the incidence of AIDS (1987 definition). Variation in CD4+ depletion appears to be mainly the result of laboratory differences. Policy recommendations on a basis of CD4+ counts probably requires a calibration of measurement. The 1993 AIDS case definition leads to a site-specific shortening of the incubation time, which complicates the study of the natural history of HIV infection and of trends in the AIDS epidemic.

Citations

May 26, 1999·The Journal of Infection·P J Easterbrook
Feb 9, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Y Adu-SarkodieG D Kanmogne
Sep 17, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara LodiUNKNOWN CASCADE Collaboration in EuroCoord
Aug 15, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A TrickettR Lam-Po-Tang
Apr 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P J VeugelersG J van Griensven
Mar 2, 2005·Retrovirology·Ben BerkhoutLia van der Hoek

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