Differences in toxicity and outcome associated with circadian variations between patients undergoing daytime and evening radiotherapy for prostate adenocarcinoma

Chronobiology International
Feng-Ming HsuJason Chia-Hsien Cheng

Abstract

This retrospective study tested the hypothesis that disease control and treatment-related toxicity in patients undergoing high-dose radiotherapy (HDRT) for prostate cancer varies in a circadian manner. Patients with localized prostate adenocarcinoma receiving HDRT (median 78 Gy) to the prostate and involved seminal vesicle(s) without elective pelvic irradiation were divided into a daytime treatment (before 5 PM) group (n = 267) and evening treatment (after 5 PM) group (n = 142). Biochemical failure (Phoenix definition), acute and late gastrointestinal (GI) and genitourinary toxicities (Common Terminology Criteria for Adverse Events version 4), biochemical failure-free survival (BFFS) and freedom from late toxicity were assessed. Analyses were performed by binary logistic regression and Cox proportional hazard regression. The median follow-up was 68 months, and 75% of patients were ≥70 years old. Evening HDRT was significantly associated with worse freedom from ≥grade 2 late GI complications (hazard ratio = 2.96; p < 0.001). The detrimental effect of evening HDRT was significant in patients older than 70 years old (p < 0.001) but not in younger patients (p = 0.63). In a subgroup of propensity score-matched cohort with T2b-T3 dis...Continue Reading

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Citations

Nov 16, 2019·Journal of Neuro-oncology·Dorela D Shuboni-MulliganTerri S Armstrong
Jul 8, 2020·Journal of Experimental & Clinical Cancer Research : CR·Han ShenEric Hau
Sep 25, 2020·Scientific Reports·Charlotte K AnderssonEva B Forssell-Aronsson
Feb 10, 2021·Chronobiology International·Lucas Gomes SapienzaEyad Abu-Isa
Mar 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eliane Koller BroleseOlgun Elicin
Apr 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Olgun ElicinNikola Cihoric
May 29, 2021·Frontiers in Oncology·Luis Bermúdez-GuzmánEduardo Lovo

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