Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

The Journal of Clinical Endocrinology and Metabolism
Max A A VogelGijs H Goossens

Abstract

Upper and lower body adipose tissue (AT) exhibits opposing associations with obesity-related cardiometabolic diseases. Recent studies have suggested that altered AT oxygen tension (pO2) may contribute to AT dysfunction. Here, we compared in vivo abdominal (ABD) and femoral (FEM) subcutaneous AT pO2 in women who are overweight and have obesity, and investigated the effects of physiological AT pO2 on human adipocyte function. ABD and FEM subcutaneous AT pO2 and AT blood flow (ATBF) were assessed in eight [BMI (body mass index) 34.4 ± 1.6 kg/m2] postmenopausal women who were overweight with obesity and impaired glucose metabolism. ABD and FEM AT biopsy specimens were collected to determine adipocyte morphology and AT gene expression. Moreover, the effects of prolonged exposure (14 days) to physiological AT pO2 on adipokine expression/secretion, mitochondrial respiration, and glucose uptake were investigated in differentiated human multipotent adipose-derived stem cells. AT pO2 was higher in ABD than FEM AT (62.7 ± 6.6 vs 50.0 ± 4.5 mm Hg, P = 0.013), whereas ATBF was comparable between depots. Maximal uncoupled oxygen consumption rates were substantially lower in ABD than FEM adipocytes for all pO2 conditions. Low physiological pO...Continue Reading

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Citations

May 12, 2019·Acta Physiologica·Ioannis G LempesisGijs H Goossens
Apr 15, 2021·Reviews in Endocrine & Metabolic Disorders·Veerle van HultenGijs H Goossens
May 1, 2021·International Journal of Molecular Sciences·Francesca PiccottiMarta Truffi
Jul 6, 2021·Molecular Metabolism·Rens L J van MeijelGijs H Goossens
Aug 17, 2021·Frontiers in Genetics·Adeline DivouxSteven R Smith

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