Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Karen A FrankwichAmir Zarrinpar

Abstract

Many companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss that are based on the results. We performed a randomized controlled trial to determine whether more participants who followed a nutrigenetic-guided diet lost ≥5% of their body weight than participants on a standard balanced diet for 8 and 24 weeks. We performed a prospective study of 51 obese or overweight U.S. veterans on an established weight management program at the Veterans Administration San Diego Healthcare System (the MOVE! program). Participants were randomly assigned to groups placed on a nutrigenetic-guided diet (balanced, low-carbohydrate, low-fat, or Mediterranean; n = 30) or a standard balanced diet (n = 21). Nutrigenetic diets were selected on the basis of results from the Pathway FIT test. There was no significant difference in the percentage of participants on the balanced diet vs the nutrigenetic-guided diet who lost 5% of their body weight at 8 weeks (35.0% ± 20.9% vs 26.9% ± 17.1%, respectively; P = .28) or at 24 weeks. Both groups had difficulty adhering to the diets. However, adherence to the nutrigenetic-guided diet correlated with weight loss (r = 0.74; P = 4.0 × 10(-5))...Continue Reading

Associated Clinical Trials

May 21, 2013·Amir Zarrinpar, MD, PhD, Amir Zarrinpar, MD, PhD

References

May 6, 2008·Nature Genetics·Ruth J F LoosKaren L Mohlke
Oct 25, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E GoyenecheaJ A Martínez
Dec 17, 2008·Nature Genetics·Cristen J WillerUNKNOWN Genetic Investigation of ANthropometric Traits Consortium
Feb 25, 2009·Obesity·Daruneewan WarodomwichitJose M Ordovas
Jul 29, 2009·Health Affairs·Eric A FinkelsteinWilliam Dietz
Aug 20, 2009·Public Health Nutrition·Denis LaironRichard Planells
Sep 4, 2009·The American Journal of Clinical Nutrition·Emily SonestedtMarju Orho-Melander
Jan 20, 2010·Journal of the American College of Cardiology·Lisa de las FuentesVictor G Davila-Roman
Jan 21, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Rena ContiScott D Grosse
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Jan 13, 2011·European Journal of Clinical Nutrition·C Stryjecki, D M Mutch

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Citations

Nov 16, 2016·Health Psychology Review·Britt AhlstromA Janet Tomiyama
Jan 21, 2017·The Proceedings of the Nutrition Society·Clare B O'DonovanEileen R Gibney
Apr 21, 2016·Circulation. Cardiovascular Genetics·Jane F FergusonUNKNOWN American Heart Association Council on Functional Genomics and Translational Biology, Council on Epidemiology and Prevention,
Jan 30, 2019·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Erin TuttySylvia A Metcalfe
Aug 12, 2015·The Proceedings of the Nutrition Society·Clare B O'DonovanLorraine Brennan
Jul 19, 2017·Annual Review of Nutrition·Nicholas J Schork, Laura H Goetz
Jun 20, 2020·Archives of Endocrinology and Metabolism·Telma Angelina Faraldo CorrêaMarcelo Macedo Rogero

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